9QJX

GABA-A receptor a2b3g2 + a2NB00(PAM) + GABA

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D (A, D)	Gamma-aminobutyric acid receptor subunit alpha-2	polymer	354	40452.4	2	UniProt (P47869)	Homo sapiens (human)	GABA(A) receptor subunit alpha-2,GABAAR subunit alpha-2
2	B, E (B, E)	Gamma-aminobutyric acid receptor subunit beta-3,Soluble cytochrome b562	polymer	451	51615.1	2	UniProt (P28472) UniProt (P0ABE7)	Homo sapiens (human)	GABA(A) receptor subunit beta-3,GABAAR subunit beta-3,Cytochrome b-562
3	C (C)	Gamma-aminobutyric acid receptor subunit gamma-2	polymer	371	42798.9	1	UniProt (P18507)	Homo sapiens (human)	GABA(A) receptor subunit gamma-2,GABAAR subunit gamma-2
4	F, G (F, G)	a2NB00	polymer	133	14391.7	2		Lama glama
5	H (H)	alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		1235.1	1	In PDB GlyTouCan (G55220VL)
6	I, M (J, O)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	2	In PDB GlyTouCan (G42666HT)
7	J (K)	alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		748.7	1	In PDB GlyTouCan (G81315DD)
8	K (I)	alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose	branched		342.3	1	In PDB GlyTouCan (G00891MP)
9	L (M)	alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		910.8	1	In PDB GlyTouCan (G22768VO)
10	N (P)	alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		1073.0	1	In PDB GlyTouCan (G09724ZC)
11	O, Q, S (A, C, D)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	3	Chemie (NAG) PubChem (24139)
12	P, R (B, D)	GAMMA-AMINO-BUTANOIC ACID	non-polymer		103.1	2	Chemie (ABU) PubChem (119)

Sequence modifications

A, D: 1 - 311 (UniProt: P47869)
A, D: 388 - 423 (UniProt: P47869)

PDB	External Database	Details
Ser 312	-	linker
Gln 313	-	linker
Pro 314	-	linker
Ala 315	-	linker
Arg 316	-	linker
Ala 317	-	linker
Ala 318	-	linker

B, E: 1 - 307 (UniProt: P28472)
B, E: 308 - 312 (UniProt: P0ABE7)

PDB	External Database	Details
Trp 308	Met 29	conflict
Ile 312	His 124	conflict
Leu 312	-	linker
Thr 312	-	linker
Gly 312	-	linker
Arg 419	-	linker
Ala 420	-	linker
Ala 421	-	linker

B, E: 422 - 448 (UniProt: P28472)

PDB	External Database	Details
Ser 308	-	linker
Gln 308	-	linker
Pro 308	-	linker
Ala 308	-	linker
Gly 308	-	linker
Thr 308	-	linker

C: 1 - 322 (UniProt: P18507)

PDB	External Database	Details
Thr 11	Ala 50	conflict

C: 409 - 436 (UniProt: P18507)

PDB	External Database	Details
Ser 402	-	linker
Gln 403	-	linker
Pro 404	-	linker
Ala 405	-	linker
Arg 406	-	linker
Ala 407	-	linker
Ala 408	-	linker
Gly 437	-	expression tag
Thr 438	-	expression tag
Gly 439	-	expression tag
Thr 440	-	expression tag
Gly 441	-	expression tag
Thr 442	-	expression tag
Glu 443	-	expression tag
Thr 444	-	expression tag
Ser 445	-	expression tag
Gln 446	-	expression tag
Val 447	-	expression tag
Ala 448	-	expression tag
Pro 449	-	expression tag
Ala 450	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	7
	Total formula weight	255717.4
Branched	Number of molecules	7
	Total formula weight	5158.7
Non-Polymers*	Number of molecules	5
	Total formula weight	869.9
All*	Total formula weight	261745.9

*Water molecules are not included.