9QJV
GABA-A receptor a2b3 (1:4) + a2NB47(silent) + b3Mb125 + GABA
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Gamma-aminobutyric acid receptor subunit alpha-2 | polymer | 365 | 41495.5 | 1 | UniProt (P47869) | Homo sapiens (human) | GABA(A) receptor subunit alpha-2,GABAAR subunit alpha-2 |
| 2 | B, C, D, E (B, C, D, E) | Gamma-aminobutyric acid receptor subunit beta-3,Soluble cytochrome b562 | polymer | 451 | 51615.1 | 4 | UniProt (P28472) UniProt (P0ABE7) | Homo sapiens (human) | GABA(A) receptor subunit beta-3,GABAAR subunit beta-3,Cytochrome b-562 |
| 3 | F (F) | a2NB47 | polymer | 138 | 15184.7 | 1 | Lama glama | ||
| 4 | G, H, I (G, H, I) | Mb125 | polymer | 133 | 14771.2 | 3 | Lama glama | ||
| 5 | J, K, L, M (M, O, Q, S) | alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1073.0 | 4 | In PDB GlyTouCan (G09724ZC) | |||
| 6 | N (A) | GAMMA-AMINO-BUTANOIC ACID | non-polymer | 103.1 | 1 | Chemie (ABU) PubChem (119) | |||
| 7 | O, P, Q, S, U... (A, B, C, D, E) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 6 | Chemie (NAG) PubChem (24139) | |||
| 8 | R, T, V (C, D, E) | HISTAMINE | non-polymer | 111.1 | 3 | Chemie (HSM) |
Sequence modifications
A: 1 - 311 (UniProt: P47869)
A: 388 - 423 (UniProt: P47869)
B, C, D, E: 1 - 307 (UniProt: P28472)
B, C, D, E: 308 - 312 (UniProt: P0ABE7)
B, C, D, E: 422 - 448 (UniProt: P28472)
A: 388 - 423 (UniProt: P47869)
| PDB | External Database | Details |
|---|---|---|
| Ser 312 | - | linker |
| Gln 313 | - | linker |
| Pro 314 | - | linker |
| Ala 315 | - | linker |
| Arg 316 | - | linker |
| Ala 317 | - | linker |
| Ala 318 | - | linker |
| Gly 424 | - | expression tag |
| Thr 425 | - | expression tag |
| Thr 426 | - | expression tag |
| Glu 427 | - | expression tag |
| Thr 428 | - | expression tag |
| Ser 429 | - | expression tag |
| Gln 430 | - | expression tag |
| Val 431 | - | expression tag |
| Ala 432 | - | expression tag |
| Pro 433 | - | expression tag |
| Ala 434 | - | expression tag |
B, C, D, E: 308 - 312 (UniProt: P0ABE7)
| PDB | External Database | Details |
|---|---|---|
| Trp 308 | Met 29 | conflict |
| Ile 312 | His 124 | conflict |
| Leu 416 | - | linker |
| Thr 417 | - | linker |
| Gly 418 | - | linker |
| Arg 419 | - | linker |
| Ala 420 | - | linker |
| Ala 421 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Ser 308 | - | linker |
| Gln 308 | - | linker |
| Pro 308 | - | linker |
| Ala 308 | - | linker |
| Gly 308 | - | linker |
| Thr 308 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 9 |
| Total formula weight | 307454.3 | |
| Branched | Number of molecules | 4 |
| Total formula weight | 4291.9 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 1763.8 | |
| All* | Total formula weight | 313509.9 |
