9QJR
GABA-A receptor a2b3 (1:4) + a2NB29(near-silent) + b3Mb125 + GABA
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Gamma-aminobutyric acid receptor subunit alpha-2 | polymer | 365 | 41495.5 | 1 | UniProt (P47869) | Homo sapiens (human) | GABA(A) receptor subunit alpha-2,GABAAR subunit alpha-2 |
| 2 | B, C, D, E (B, C, D, E) | Gamma-aminobutyric acid receptor subunit beta-3,Gamma-aminobutyric acid receptor subunit beta-3,Gamma-aminobutyric acid receptor subunit beta-3,Soluble cytochrome b562 | polymer | 451 | 51615.1 | 4 | UniProt (P28472) | Homo sapiens (human) | GABA(A) receptor subunit beta-3,GABAAR subunit beta-3 |
| 3 | F (F) | a2 nanobody 29 | polymer | 140 | 15184.5 | 1 | Lama glama | ||
| 4 | G, H, I (G, H, I) | megabody 125 | polymer | 522 | 56300.6 | 3 | Lama glama | ||
| 5 | J, L, N, P (K, M, O, Q) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 4 | In PDB GlyTouCan (G42666HT) | |||
| 6 | K, M, O, Q (L, N, P, R) | alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1073.0 | 4 | In PDB GlyTouCan (G09724ZC) | |||
| 7 | R (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) PubChem (24139) | |||
| 8 | S (B) | GAMMA-AMINO-BUTANOIC ACID | non-polymer | 103.1 | 1 | Chemie (ABU) PubChem (119) | |||
| 9 | T, U, V (C, D, E) | HISTAMINE | non-polymer | 111.1 | 3 | Chemie (HSM) |
Sequence modifications
A: 1 - 311 (UniProt: P47869)
A: 388 - 423 (UniProt: P47869)
B, C, D, E: 1 - 307 (UniProt: P28472)
B, C, D, E: 308 - 421 (PDB: 9QJR)
B, C, D, E: 422 - 448 (UniProt: P28472)
A: 388 - 423 (UniProt: P47869)
| PDB | External Database | Details |
|---|---|---|
| Ser 312 | - | linker |
| Gln 313 | - | linker |
| Pro 314 | - | linker |
| Ala 315 | - | linker |
| Arg 316 | - | linker |
| Ala 317 | - | linker |
| Ala 318 | - | linker |
| Gly 424 | - | expression tag |
| Thr 425 | - | expression tag |
| Thr 426 | - | expression tag |
| Glu 427 | - | expression tag |
| Thr 428 | - | expression tag |
| Ser 429 | - | expression tag |
| Gln 430 | - | expression tag |
| Val 431 | - | expression tag |
| Ala 432 | - | expression tag |
| Pro 433 | - | expression tag |
| Ala 434 | - | expression tag |
B, C, D, E: 308 - 421 (PDB: 9QJR)
B, C, D, E: 422 - 448 (UniProt: P28472)
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 9 |
| Total formula weight | 432042.3 | |
| Branched | Number of molecules | 8 |
| Total formula weight | 5989.5 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 657.8 | |
| All* | Total formula weight | 438689.6 |
