9QIW

Human pre-60S - State 3

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (CA)	Eukaryotic translation initiation factor 6	polymer	245	26620.0	1	UniProt (P56537) Pfam (PF01912)	Homo sapiens (human)	eIF-6,B(2)GCN homolog,B4 integrin interactor,CAB,p27(BBP)
2	B (CB)	Nucleolar GTP-binding protein 2	polymer	731	83796.1	1	UniProt (Q13823) Pfam (PF08153) Pfam (PF01926)	Homo sapiens (human)	Autoantigen NGP-1
3	C (CC)	Guanine nucleotide-binding protein-like 3	polymer	549	62098.2	1	UniProt (Q9BVP2) Pfam (PF08701) Pfam (PF01926)	Homo sapiens (human)	E2-induced gene 3 protein,Novel nucleolar protein 47,NNP47,Nucleolar GTP-binding protein 3,Nucleostemin
4	D (CD)	GTP-binding protein 4	polymer	634	74107.8	1	UniProt (Q9BZE4) Pfam (PF17835) Pfam (PF06858) Pfam (PF08155)	Homo sapiens (human)	Chronic renal failure gene protein,GTP-binding protein NGB,Nucleolar GTP-binding protein 1
5	E (CE)	Protein LLP homolog	polymer	129	15268.4	1	UniProt (Q9BRT6) Pfam (PF10169)	Homo sapiens (human)	Protein LAPS18-like
6	F (CF)	mRNA turnover protein 4 homolog	polymer	239	27602.5	1	UniProt (Q9UKD2) Pfam (PF00466) Pfam (PF17777)	Homo sapiens (human)	Ribosome assembly factor MRTO4
7	G (CG)	Notchless protein homolog 1	polymer	485	53329.1	1	UniProt (Q9NVX2) Pfam (PF08154) Pfam (PF00400)	Homo sapiens (human)
8	H (CH)	Ribosome biogenesis protein NSA2 homolog	polymer	260	30136.7	1	UniProt (O95478) Pfam (PF01201)	Homo sapiens (human)	Hairy cell leukemia protein 1,TGF-beta-inducible nuclear protein 1
9	I (CI)	Probable ribosome biogenesis protein RLP24	polymer	163	19666.3	1	UniProt (Q9UHA3) Pfam (PF01246)	Homo sapiens (human)	Ribosomal L24 domain-containing protein 1,Ribosomal protein L24-like
10	J (CJ)	Ribosome production factor 2 homolog	polymer	306	35658.1	1	UniProt (Q9H7B2) Pfam (PF04427)	Homo sapiens (human)	Brix domain-containing protein 1,Ribosome biogenesis protein RPF2 homolog
11	K (CK)	Ribosome biogenesis regulatory protein homolog	polymer	365	41278.5	1	UniProt (Q15050) Pfam (PF04939)	Homo sapiens (human)
12	L (L7)	5S rRNA	polymer	121	38998.1	1	GenBank (23898)	Homo sapiens (human)
13	M (LA)	60S ribosomal protein L8	polymer	257	28088.9	1	UniProt (P62917) Pfam (PF00181) Pfam (PF03947)	Homo sapiens (human)	Large ribosomal subunit protein uL2
14	N (LB)	60S ribosomal protein L3	polymer	403	46211.1	1	UniProt (P39023) Pfam (PF00297)	Homo sapiens (human)	HIV-1 TAR RNA-binding protein B,TARBP-B,Large ribosomal subunit protein uL3
15	O (LC)	60S ribosomal protein L4	polymer	427	47804.6	1	UniProt (P36578) Pfam (PF00573) Pfam (PF14374)	Homo sapiens (human)	60S ribosomal protein L1,Large ribosomal subunit protein uL4
16	P (LD)	60S ribosomal protein L5	polymer	297	34426.8	1	UniProt (P46777) Pfam (PF17144) Pfam (PF14204)	Homo sapiens (human)	Large ribosomal subunit protein uL18
17	Q (LE)	Large ribosomal subunit protein eL6	polymer	288	32810.2	1	UniProt (Q02878) Pfam (PF03868) Pfam (PF01159)	Homo sapiens (human)	60S ribosomal protein L6,Neoplasm-related protein C140,Tax-responsive enhancer element-binding protein 107,TaxREB107
18	R (LF)	Large ribosomal subunit protein uL30	polymer	248	29291.0	1	UniProt (P18124) Pfam (PF08079) Pfam (PF00327)	Homo sapiens (human)	60S ribosomal protein L7
19	S (LG)	60S ribosomal protein L7a	polymer	266	30061.8	1	UniProt (P62424) Pfam (PF01248)	Homo sapiens (human)	Large ribosomal subunit protein eL8,PLA-X polypeptide,Surfeit locus protein 3
20	T (LH)	60S ribosomal protein L9	polymer	192	21899.5	1	UniProt (P32969) Pfam (PF00347)	Homo sapiens (human)	Large ribosomal subunit protein uL6
21	U (LJ)	60S ribosomal protein L11	polymer	178	20288.5	1	UniProt (P62913) Pfam (PF00281) Pfam (PF00673)	Homo sapiens (human)	CLL-associated antigen KW-12,Large ribosomal subunit protein uL5
22	V (LL)	60S ribosomal protein L13	polymer	211	24321.7	1	UniProt (P26373) Pfam (PF01294)	Homo sapiens (human)	Breast basic conserved protein 1,Large ribosomal subunit protein eL13
23	W (LM)	60S ribosomal protein L14	polymer	215	23485.0	1	UniProt (P50914) Pfam (PF01929)	Homo sapiens (human)	CAG-ISL 7,Large ribosomal subunit protein eL14
24	X (LN)	60S ribosomal protein L15	polymer	204	24207.3	1	UniProt (P61313) Pfam (PF00827)	Homo sapiens (human)	Large ribosomal subunit protein eL15
25	Y (LO)	60S ribosomal protein L13a	polymer	203	23633.4	1	UniProt (P40429) Pfam (PF00572)	Homo sapiens (human)	23 kDa highly basic protein,Large ribosomal subunit protein uL13
26	Z (LP)	60S ribosomal protein L17	polymer	184	21443.2	1	UniProt (P18621) Pfam (PF00237)	Homo sapiens (human)	60S ribosomal protein L23,Large ribosomal subunit protein uL22,PD-1
27	AA (LQ)	60S ribosomal protein L18	polymer	188	21687.7	1	UniProt (Q07020) Pfam (PF17135)	Homo sapiens (human)	Large ribosomal subunit protein eL18
28	BA (LR)	60S ribosomal protein L19	polymer	196	23535.3	1	UniProt (P84098) Pfam (PF01280) Pfam (PF25476)	Homo sapiens (human)	Large ribosomal subunit protein eL19
29	CA (LS)	60S ribosomal protein L18a	polymer	176	20808.5	1	UniProt (Q02543) Pfam (PF01775)	Homo sapiens (human)	Large ribosomal subunit protein eL20
30	DA (LT)	60S ribosomal protein L21	polymer	160	18610.0	1	UniProt (P46778) Pfam (PF01157)	Homo sapiens (human)	Large ribosomal subunit protein eL21
31	EA (LU)	60S ribosomal protein L22	polymer	128	14813.0	1	UniProt (P35268) Pfam (PF01776)	Homo sapiens (human)	EBER-associated protein,EAP,Epstein-Barr virus small RNA-associated protein,Heparin-binding protein HBp15,Large ribosomal subunit protein eL22
32	FA (LV)	60S ribosomal protein L23	polymer	140	14892.5	1	UniProt (P62829) Pfam (PF00238)	Homo sapiens (human)	60S ribosomal protein L17,Large ribosomal subunit protein uL14
33	GA (LX)	60S ribosomal protein L23a	polymer	156	17740.2	1	UniProt (P62750) Pfam (PF03939) Pfam (PF00276)	Homo sapiens (human)	Large ribosomal subunit protein uL23
34	HA (LY)	60S ribosomal protein L26	polymer	145	17303.4	1	UniProt (P61254) Pfam (PF16906) Pfam (PF00467)	Homo sapiens (human)	Large ribosomal subunit protein uL24
35	IA (LZ)	60S ribosomal protein L27	polymer	136	15835.8	1	UniProt (P61353) Pfam (PF00467) Pfam (PF01777)	Homo sapiens (human)	Large ribosomal subunit protein eL27
36	JA (La)	60S ribosomal protein L27a	polymer	148	16604.5	1	UniProt (P46776) Pfam (PF00828)	Homo sapiens (human)	Large ribosomal subunit protein uL15
37	KA (Lc)	60S ribosomal protein L30	polymer	115	12805.1	1	UniProt (P62888) Pfam (PF01248)	Homo sapiens (human)	Large ribosomal subunit protein eL30
38	LA (Ld)	60S ribosomal protein L31	polymer	125	14494.9	1	UniProt (P62899) Pfam (PF01198)	Homo sapiens (human)	Large ribosomal subunit protein eL31
39	MA (Le)	60S ribosomal protein L32	polymer	135	15898.9	1	UniProt (P62910) Pfam (PF01655)	Homo sapiens (human)	Large ribosomal subunit protein eL32
40	NA (Lf)	60S ribosomal protein L35a	polymer	110	12564.7	1	UniProt (P18077) Pfam (PF01247)	Homo sapiens (human)	Cell growth-inhibiting gene 33 protein,Large ribosomal subunit protein eL33
41	OA (Lg)	60S ribosomal protein L34	polymer	117	13326.1	1	UniProt (P49207) Pfam (PF01199)	Homo sapiens (human)	Large ribosomal subunit protein eL34
42	PA (Lh)	60S ribosomal protein L35	polymer	123	14593.6	1	UniProt (P42766) Pfam (PF00831)	Homo sapiens (human)	Large ribosomal subunit protein uL29
43	QA (Li)	60S ribosomal protein L36	polymer	105	12290.9	1	UniProt (Q9Y3U8) Pfam (PF01158)	Homo sapiens (human)	Large ribosomal subunit protein eL36
44	RA (Lj)	Large ribosomal subunit protein eL37	polymer	97	11111.0	1	UniProt (P61927) Pfam (PF01907)	Homo sapiens (human)	60S ribosomal protein L37,G1.16
45	SA (Lk)	60S ribosomal protein L38	polymer	70	8238.9	1	UniProt (P63173) Pfam (PF01781)	Homo sapiens (human)	Large ribosomal subunit protein eL38
46	TA (Ll)	60S ribosomal protein L39	polymer	51	6426.8	1	UniProt (P62891) Pfam (PF00832)	Homo sapiens (human)	Large ribosomal subunit protein eL39
47	UA (Lp)	60S ribosomal protein L37a	polymer	92	10299.4	1	UniProt (P61513) Pfam (PF01780)	Homo sapiens (human)	Large ribosomal subunit protein eL43
48	VA (Lr)	60S ribosomal protein L28	polymer	137	15784.6	1	UniProt (P46779) Pfam (PF01778)	Homo sapiens (human)	Large ribosomal subunit protein eL28
49	WA (Lt)	Large ribosomal subunit protein uL11	polymer	165	17847.6	1	UniProt (P30050) Pfam (PF03946) Pfam (PF00298)	Homo sapiens (human)	60S ribosomal protein L12
50	XA (L5)	28S rRNA	polymer	5070	1640222.1	1	GenBank (NR_003287)	Homo sapiens (human)
51	YA (L8)	5.8S rRNA	polymer	157	50449.8	1	GenBank (555853)	Homo sapiens (human)
52	ZA (CB)	GUANOSINE-5'-TRIPHOSPHATE	non-polymer		523.2	1	Chemie (GTP) PubChem (177679032) PubChem (135400627) PubChem (135487750) PubChem (136088935) PubChem (136803486) PubChem (135398633) PubChem (135544356) PubChem (135547949) PubChem (135600366) PubChem (135749822) PubChem (136005188) PubChem (136073923) PubChem (136240914) PubChem (136664747) PubChem (136772743) PubChem (136772744) PubChem (136803487) PubChem (137286749) PubChem (164715984) PubChem (171699466)
53	AB (CD)	GUANOSINE-5'-DIPHOSPHATE	non-polymer		443.2	1	Chemie (GDP) PubChem (136073927) PubChem (135398619) PubChem (135402030) PubChem (135431654) PubChem (135566337) PubChem (135760556) PubChem (136026707) PubChem (136053418) PubChem (136663964) PubChem (136664748) PubChem (136759848) PubChem (136759849) PubChem (136759850) PubChem (136836636) PubChem (136847074) PubChem (172898537)
54	BB (CD)	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG) PubChem (888)
55	CB, DB, EB, FB (CI, Lg, Lj, Lp)	ZINC ION	non-polymer		65.4	4	Chemie (ZN)

Sequence modifications

CG: 1 - 485 (UniProt: Q9NVX2)

PDB	External Database	Details
Ala 85	Glu 85	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	51
	Total formula weight	2954718.1
Non-Polymers*	Number of molecules	7
	Total formula weight	1252.3
All*	Total formula weight	2955970.4

*Water molecules are not included.