9QI7
Crystal structure of I105R mutant of BlaC from Mycobacterium tuberculosis in complex with avibactam
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Beta-lactamase | polymer | 264 | 28201.7 | 1 | UniProt (P0A5I7) Pfam (PF13354) UniProt (by SIFTS) (P9WKD3) | Mycobacterium tuberculosis | Ambler class A beta-lactamase |
| 2 | B (A) | (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide | non-polymer | 267.3 | 1 | Chemie (NXL) | |||
| 3 | C (A) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
| 4 | D, E (A) | ACETATE ION | non-polymer | 59.0 | 2 | Chemie (ACT) | |||
| 5 | F (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 6 | G, H (A) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 7 | I (A) | water | water | 18.0 | 34 | Chemie (HOH) |
Sequence modifications
A: 29 - 293 (UniProt: P0A5I7)
| PDB | External Database | Details |
|---|---|---|
| Arg 105 | Ile 117 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 28201.7 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 714.4 | |
| All* | Total formula weight | 28916.1 |
