9QHQ
Cryo-EM structure of mouse TRPM3 alpha 2 in with agonists CIM-0216 and Pregnenolone sulfate (PregS)
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | MKIAA1616 protein | polymer | 1409 | 161963.3 | 4 | UniProt (Q69ZE8) | Mus musculus (house mouse) | |
| 2 | E, J, L, P (A, B, C, D) | (2~{R})-2-(3,4-dihydro-2~{H}-quinolin-1-yl)-~{N}-(5-methyl-1,2-oxazol-3-yl)-2-phenyl-ethanamide | non-polymer | 347.4 | 4 | Chemie (A1I8P) | |||
| 3 | F, I, M, O (A, B, C, D) | Pregnenolone sulfate | non-polymer | 396.5 | 4 | Chemie (A8W) | |||
| 4 | G, H, K, N (A, C, D) | CHOLESTEROL | non-polymer | 386.7 | 4 | Chemie (CLR) |
Sequence modifications
A, B, C, D: 2 - 1344 (UniProt: Q69ZE8)
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | initiating methionine |
| Ser 1 | - | expression tag |
| Ala 1345 | - | expression tag |
| Leu 1346 | - | expression tag |
| Glu 1347 | - | expression tag |
| Val 1348 | - | expression tag |
| Leu 1349 | - | expression tag |
| Phe 1350 | - | expression tag |
| Gln 1351 | - | expression tag |
| Gly 1352 | - | expression tag |
| Pro 1353 | - | expression tag |
| Gln 1354 | - | expression tag |
| Gly 1355 | - | expression tag |
| Thr 1356 | - | expression tag |
| Glu 1357 | - | expression tag |
| Gln 1358 | - | expression tag |
| Lys 1359 | - | expression tag |
| Leu 1360 | - | expression tag |
| Ile 1361 | - | expression tag |
| Ser 1362 | - | expression tag |
| Glu 1363 | - | expression tag |
| Glu 1364 | - | expression tag |
| Asp 1365 | - | expression tag |
| Leu 1366 | - | expression tag |
| Arg 1367 | - | expression tag |
| Gly 1368 | - | expression tag |
| Ala 1369 | - | expression tag |
| Ser 1370 | - | expression tag |
| Met 1371 | - | expression tag |
| Asp 1372 | - | expression tag |
| Glu 1373 | - | expression tag |
| Lys 1374 | - | expression tag |
| Thr 1375 | - | expression tag |
| Thr 1376 | - | expression tag |
| Gly 1377 | - | expression tag |
| Trp 1378 | - | expression tag |
| Arg 1379 | - | expression tag |
| Gly 1380 | - | expression tag |
| Gly 1381 | - | expression tag |
| His 1382 | - | expression tag |
| Val 1383 | - | expression tag |
| Val 1384 | - | expression tag |
| Glu 1385 | - | expression tag |
| Gly 1386 | - | expression tag |
| Leu 1387 | - | expression tag |
| Ala 1388 | - | expression tag |
| Gly 1389 | - | expression tag |
| Glu 1390 | - | expression tag |
| Leu 1391 | - | expression tag |
| Glu 1392 | - | expression tag |
| Gln 1393 | - | expression tag |
| Leu 1394 | - | expression tag |
| Arg 1395 | - | expression tag |
| Ala 1396 | - | expression tag |
| Arg 1397 | - | expression tag |
| Leu 1398 | - | expression tag |
| Glu 1399 | - | expression tag |
| His 1400 | - | expression tag |
| His 1401 | - | expression tag |
| Pro 1402 | - | expression tag |
| Gln 1403 | - | expression tag |
| Gly 1404 | - | expression tag |
| Gln 1405 | - | expression tag |
| Arg 1406 | - | expression tag |
| Glu 1407 | - | expression tag |
| Pro 1408 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 647853.0 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 4522.4 | |
| All* | Total formula weight | 652375.4 |
