9QEM

Crystal structure of YTHDF2 in complex with compound 3 (AI-DF2-11)

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	YTH domain-containing family protein 2	polymer	167	19367.8	2	UniProt (Q9Y5A9)	Homo sapiens (human)	CLL-associated antigen KW-14,High-glucose-regulated protein 8,Renal carcinoma antigen NY-REN-2
2	C, I (A, B)	5-[[(3-methoxyphenyl)amino]methylidene]-2-sulfanylidene-1,3-diazinane-4,6-dione	non-polymer		277.3	2	Chemie (A1I56)
3	D, E (A)	GLYCEROL	non-polymer		92.1	2	Chemie (GOL)
4	F, G, J, K, L (A, B)	SULFATE ION	non-polymer		96.1	5	Chemie (SO4)
5	H (A)	CHLORIDE ION	non-polymer		35.5	1	Chemie (CL)
6	M, N (A, B)	water	water		18.0	31	Chemie (HOH)

Sequence modifications

A, B: 408 - 552 (UniProt: Q9Y5A9)

PDB	External Database	Details
Met 386	-	initiating methionine
Gly 387	-	expression tag
Ser 388	-	expression tag
Ser 389	-	expression tag
Tyr 390	-	expression tag
His 391	-	expression tag
His 392	-	expression tag
His 393	-	expression tag
His 394	-	expression tag
His 395	-	expression tag
His 396	-	expression tag
Ser 397	-	expression tag
Ser 398	-	expression tag
Gly 399	-	expression tag
Glu 400	-	expression tag
Asn 401	-	expression tag
Leu 402	-	expression tag
Tyr 403	-	expression tag
Phe 404	-	expression tag
Gln 405	-	expression tag
His 406	-	expression tag
Met 407	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	38735.7
Non-Polymers*	Number of molecules	10
	Total formula weight	1254.6
All*	Total formula weight	39990.3

*Water molecules are not included.