9QEK
Structure of Human ROS1 Kinase Domain Harboring the G2032R Solvent-front Mutation in Complex with Zidesamtinib (NVL-520)
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Proto-oncogene tyrosine-protein kinase ROS | polymer | 301 | 34540.8 | 1 | UniProt (P08922) Pfam (PF07714) | Homo sapiens (human) | Proto-oncogene c-Ros,Proto-oncogene c-Ros-1,Receptor tyrosine kinase c-ros oncogene 1,c-Ros receptor tyrosine kinase |
| 2 | B (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 3 | C (A) | Zidesamtinib | non-polymer | 419.5 | 1 | Chemie (A1I6Z) | |||
| 4 | D (A) | water | water | 18.0 | 42 | Chemie (HOH) |
Sequence modifications
A: 1934 - 2232 (UniProt: P08922)
| PDB | External Database | Details |
|---|---|---|
| Gly 1932 | - | expression tag |
| Ser 1933 | - | expression tag |
| Arg 2032 | Gly 2032 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 34540.8 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 481.5 | |
| All* | Total formula weight | 35022.4 |
