9QEH
Cryo-EM structure of the A2085-methylated 50S ribosome of a MLSb resistant S. aureus strain "MNY196" in complex with solithromycin
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (1) | Large ribosomal subunit protein bL33A | polymer | 52 | 6305.3 | 1 | UniProt (Q2FH98) | Staphylococcus aureus subsp. aureus USA300 | 50S ribosomal protein L33 1 |
| 2 | B (2) | Large ribosomal subunit protein bL34 | polymer | 45 | 5454.6 | 1 | UniProt (Q2FDE6) | Staphylococcus aureus subsp. aureus USA300 | 50S ribosomal protein L34 |
| 3 | C (3) | Large ribosomal subunit protein bL35 | polymer | 66 | 7722.4 | 1 | UniProt (Q2FG57) | Staphylococcus aureus subsp. aureus USA300 | 50S ribosomal protein L35 |
| 4 | D (4) | Large ribosomal subunit protein bL36 | polymer | 37 | 4318.4 | 1 | UniProt (Q2FER2) | Staphylococcus aureus subsp. aureus USA300 | 50S ribosomal protein L36 |
| 5 | E (L) | Large ribosomal subunit protein bL17 | polymer | 122 | 13771.8 | 1 | UniProt (Q2FER6) | Staphylococcus aureus subsp. aureus USA300 | 50S ribosomal protein L17 |
| 6 | F (A) | 23S rRNA | polymer | 2923 | 946850.8 | 1 | Staphylococcus aureus subsp. aureus USA300 | ||
| 7 | G (B) | 5S rRNA | polymer | 115 | 36974.9 | 1 | GenBank (1760048038) | Staphylococcus aureus subsp. aureus USA300 | |
| 8 | H (C) | Large ribosomal subunit protein uL2 | polymer | 277 | 30217.2 | 1 | UniProt (Q2FEP2) | Staphylococcus aureus subsp. aureus USA300 | 50S ribosomal protein L2 |
| 9 | I (D) | Large ribosomal subunit protein uL3 | polymer | 220 | 23760.3 | 1 | UniProt (Q2FEN9) | Staphylococcus aureus subsp. aureus USA300 | 50S ribosomal protein L3 |
| 10 | J (E) | Large ribosomal subunit protein uL4 | polymer | 207 | 22495.7 | 1 | UniProt (Q2FEP0) | Staphylococcus aureus subsp. aureus USA300 | 50S ribosomal protein L4 |
| 11 | K (F) | Large ribosomal subunit protein uL5 | polymer | 179 | 20296.6 | 1 | UniProt (Q2FEQ1) | Staphylococcus aureus subsp. aureus USA300 | 50S ribosomal protein L5 |
| 12 | L (G) | Large ribosomal subunit protein uL6 | polymer | 178 | 19818.6 | 1 | UniProt (Q2FEQ4) | Staphylococcus aureus subsp. aureus USA300 | 50S ribosomal protein L6 |
| 13 | M (H) | Large ribosomal subunit protein uL13 | polymer | 145 | 16359.4 | 1 | UniProt (Q2FES1) | Staphylococcus aureus subsp. aureus USA300 | 50S ribosomal protein L13 |
| 14 | N (I) | Large ribosomal subunit protein uL14 | polymer | 122 | 13157.3 | 1 | UniProt (Q2FEP9) | Staphylococcus aureus subsp. aureus USA300 | 50S ribosomal protein L14 |
| 15 | O (J) | Large ribosomal subunit protein uL15 | polymer | 146 | 15628.9 | 1 | UniProt (Q2FEQ8) | Staphylococcus aureus subsp. aureus USA300 | 50S ribosomal protein L15 |
| 16 | P (K) | Large ribosomal subunit protein uL16 | polymer | 144 | 16274.0 | 1 | UniProt (Q2FEP6) | Staphylococcus aureus subsp. aureus USA300 | 50S ribosomal protein L16 |
| 17 | Q (M) | Large ribosomal subunit protein uL18 | polymer | 119 | 13124.1 | 1 | UniProt (Q2FEQ5) | Staphylococcus aureus subsp. aureus USA300 | 50S ribosomal protein L18 |
| 18 | R (N) | Large ribosomal subunit protein bL19 | polymer | 116 | 13392.8 | 1 | UniProt (Q2FHJ7) | Staphylococcus aureus subsp. aureus USA300 | 50S ribosomal protein L19 |
| 19 | S (O) | Large ribosomal subunit protein bL20 | polymer | 118 | 13720.3 | 1 | UniProt (Q2FG58) | Staphylococcus aureus subsp. aureus USA300 | 50S ribosomal protein L20 |
| 20 | T (P) | Large ribosomal subunit protein bL21 | polymer | 102 | 11354.1 | 1 | UniProt (Q2FG80) | Staphylococcus aureus subsp. aureus USA300 | 50S ribosomal protein L21 |
| 21 | U (Q) | Large ribosomal subunit protein uL22 | polymer | 117 | 12857.9 | 1 | UniProt (Q2FEP4) | Staphylococcus aureus subsp. aureus USA300 | 50S ribosomal protein L22 |
| 22 | V (R) | Large ribosomal subunit protein uL23 | polymer | 91 | 10625.4 | 1 | UniProt (Q2FEP1) | Staphylococcus aureus subsp. aureus USA300 | 50S ribosomal protein L23 |
| 23 | W (S) | Large ribosomal subunit protein uL24 | polymer | 105 | 11561.5 | 1 | UniProt (Q2FEQ0) | Staphylococcus aureus subsp. aureus USA300 | 50S ribosomal protein L24 |
| 24 | X (T) | 50S ribosomal protein L25 | polymer | 217 | 23810.6 | 1 | UniProt (Q2FJE0) | Staphylococcus aureus subsp. aureus USA300 | General stress protein CTC |
| 25 | Y (U) | Large ribosomal subunit protein bL27 | polymer | 94 | 10334.8 | 1 | UniProt (Q2FG82) | Staphylococcus aureus subsp. aureus USA300 | 50S ribosomal protein L27 |
| 26 | Z (V) | Large ribosomal subunit protein bL28 | polymer | 62 | 6995.3 | 1 | UniProt (Q2FHL4) | Staphylococcus aureus subsp. aureus USA300 | 50S ribosomal protein L28 |
| 27 | AA (W) | Large ribosomal subunit protein uL29 | polymer | 73 | 8592.9 | 1 | UniProt (A0A0H2XHC7) | Staphylococcus aureus subsp. aureus USA300 | |
| 28 | BA (X) | Large ribosomal subunit protein uL30 | polymer | 59 | 6565.7 | 1 | UniProt (Q2FEQ7) | Staphylococcus aureus subsp. aureus USA300 | 50S ribosomal protein L30 |
| 29 | CA (Z) | Large ribosomal subunit protein bL32 | polymer | 57 | 6500.6 | 1 | UniProt (Q2FHV3) | Staphylococcus aureus subsp. aureus USA300 | 50S ribosomal protein L32 |
| 30 | DA (8) | P_site tRNA | polymer | 71 | 22969.7 | 1 | Staphylococcus aureus subsp. aureus USA300 | ||
| 31 | EA (11) | E_site tRNA | polymer | 13 | 4170.6 | 1 | Staphylococcus aureus subsp. aureus USA300 | ||
| 32 | FA, GA, RJ (1, 4, Z) | ZINC ION | non-polymer | 65.4 | 3 | Chemie (ZN) | |||
| 33 | AB, AC, AD, AE, AF... (A, L, D, J, U) | MAGNESIUM ION | non-polymer | 24.3 | 231 | Chemie (MG) | |||
| 34 | IA (A) | (3aS,4R,7S,9R,10R,11R,13R,15R,15aR)-1-{4-[4-(3-aminophenyl)-1H-1,2,3-triazol-1-yl]butyl}-4-ethyl-7-fluoro-11-methoxy-3a ,7,9,11,13,15-hexamethyl-2,6,8,14-tetraoxotetradecahydro-2H-oxacyclotetradecino[4,3-d][1,3]oxazol-10-yl 3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranoside | non-polymer | 845.0 | 1 | Chemie (EM1) | |||
| 35 | CJ, DJ, EJ, FJ, GJ... (A, C) | POTASSIUM ION | non-polymer | 39.1 | 12 | Chemie (K) | |||
| 36 | AK, BK, CK, SJ, TJ... (O, R, X, 3, A...) | water | water | 18.0 | 665 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 31 |
| Total formula weight | 1375982.5 | |
| Non-Polymers* | Number of molecules | 247 |
| Total formula weight | 7124.9 | |
| All* | Total formula weight | 1383107.4 |
