9QEG
Cryo-EM structure of the 70S ribosome of a MLSb sensitive S. aureus strain "KES34" in complex with solithromycin
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (1) | Large ribosomal subunit protein bL33A | polymer | 52 | 6305.3 | 1 | UniProt (Q2FH98) | Staphylococcus aureus subsp. aureus USA300 | 50S ribosomal protein L33 1 |
| 2 | B (2) | Large ribosomal subunit protein bL34 | polymer | 45 | 5454.6 | 1 | UniProt (Q2FDE6) | Staphylococcus aureus subsp. aureus USA300 | 50S ribosomal protein L34 |
| 3 | C (3) | Large ribosomal subunit protein bL35 | polymer | 66 | 7722.4 | 1 | UniProt (Q2FG57) | Staphylococcus aureus subsp. aureus USA300 | 50S ribosomal protein L35 |
| 4 | D (4) | Large ribosomal subunit protein bL36 | polymer | 37 | 4318.4 | 1 | UniProt (Q2FER2) | Staphylococcus aureus subsp. aureus USA300 | 50S ribosomal protein L36 |
| 5 | E (B) | 5S ribosomal RNA | polymer | 115 | 36975.9 | 1 | GenBank (1335862171) | Staphylococcus aureus subsp. aureus USA300 | |
| 6 | F (C) | Large ribosomal subunit protein uL2 | polymer | 277 | 30217.2 | 1 | UniProt (Q2FEP2) | Staphylococcus aureus subsp. aureus USA300 | 50S ribosomal protein L2 |
| 7 | G (D) | Large ribosomal subunit protein uL3 | polymer | 220 | 23760.3 | 1 | UniProt (Q2FEN9) | Staphylococcus aureus subsp. aureus USA300 | 50S ribosomal protein L3 |
| 8 | H (E) | Large ribosomal subunit protein uL4 | polymer | 207 | 22495.7 | 1 | UniProt (Q2FEP0) | Staphylococcus aureus subsp. aureus USA300 | 50S ribosomal protein L4 |
| 9 | I (G) | Large ribosomal subunit protein uL6 | polymer | 178 | 19818.6 | 1 | UniProt (Q2FEQ4) | Staphylococcus aureus subsp. aureus USA300 | 50S ribosomal protein L6 |
| 10 | J (H) | Large ribosomal subunit protein uL13 | polymer | 145 | 16359.4 | 1 | UniProt (Q2FES1) | Staphylococcus aureus subsp. aureus USA300 | 50S ribosomal protein L13 |
| 11 | K (I) | Large ribosomal subunit protein uL14 | polymer | 122 | 13157.3 | 1 | UniProt (Q2FEP9) | Staphylococcus aureus subsp. aureus USA300 | 50S ribosomal protein L14 |
| 12 | L (J) | Large ribosomal subunit protein uL15 | polymer | 146 | 15628.9 | 1 | UniProt (Q2FEQ8) | Staphylococcus aureus subsp. aureus USA300 | 50S ribosomal protein L15 |
| 13 | M (K) | Large ribosomal subunit protein uL16 | polymer | 144 | 16274.0 | 1 | UniProt (Q2FEP6) | Staphylococcus aureus subsp. aureus USA300 | 50S ribosomal protein L16 |
| 14 | N (L) | Large ribosomal subunit protein bL17 | polymer | 122 | 13771.8 | 1 | UniProt (Q2FER6) | Staphylococcus aureus subsp. aureus USA300 | 50S ribosomal protein L17 |
| 15 | O (M) | Large ribosomal subunit protein uL18 | polymer | 119 | 13124.1 | 1 | UniProt (Q2FEQ5) | Staphylococcus aureus subsp. aureus USA300 | 50S ribosomal protein L18 |
| 16 | P (N) | Large ribosomal subunit protein bL19 | polymer | 116 | 13392.8 | 1 | UniProt (Q2FHJ7) | Staphylococcus aureus subsp. aureus USA300 | 50S ribosomal protein L19 |
| 17 | Q (O) | Large ribosomal subunit protein bL20 | polymer | 118 | 13720.3 | 1 | UniProt (Q2FG58) | Staphylococcus aureus subsp. aureus USA300 | 50S ribosomal protein L20 |
| 18 | R (P) | Large ribosomal subunit protein bL21 | polymer | 102 | 11354.1 | 1 | UniProt (Q2FG80) | Staphylococcus aureus subsp. aureus USA300 | 50S ribosomal protein L21 |
| 19 | S (Q) | Large ribosomal subunit protein uL22 | polymer | 117 | 12857.9 | 1 | UniProt (Q2FEP4) | Staphylococcus aureus subsp. aureus USA300 | 50S ribosomal protein L22 |
| 20 | T (R) | Large ribosomal subunit protein uL23 | polymer | 91 | 10625.4 | 1 | UniProt (Q2FEP1) | Staphylococcus aureus subsp. aureus USA300 | 50S ribosomal protein L23 |
| 21 | U (S) | Large ribosomal subunit protein uL24 | polymer | 105 | 11561.5 | 1 | UniProt (Q2FEQ0) | Staphylococcus aureus subsp. aureus USA300 | 50S ribosomal protein L24 |
| 22 | V (T) | 50S ribosomal protein L25 | polymer | 217 | 23810.6 | 1 | UniProt (Q2FJE0) | Staphylococcus aureus subsp. aureus USA300 | General stress protein CTC |
| 23 | W (U) | Large ribosomal subunit protein bL27 | polymer | 94 | 10334.8 | 1 | UniProt (Q2FG82) | Staphylococcus aureus subsp. aureus USA300 | 50S ribosomal protein L27 |
| 24 | X (V) | Large ribosomal subunit protein bL28 | polymer | 62 | 6995.3 | 1 | UniProt (Q2FHL4) | Staphylococcus aureus subsp. aureus USA300 | 50S ribosomal protein L28 |
| 25 | Y (W) | Large ribosomal subunit protein uL29 | polymer | 73 | 8592.9 | 1 | UniProt (A0A0H2XHC7) | Staphylococcus aureus subsp. aureus USA300 | |
| 26 | Z (X) | Large ribosomal subunit protein uL30 | polymer | 59 | 6565.7 | 1 | UniProt (Q2FEQ7) | Staphylococcus aureus subsp. aureus USA300 | 50S ribosomal protein L30 |
| 27 | AA (Z) | Large ribosomal subunit protein bL32 | polymer | 57 | 6500.6 | 1 | UniProt (Q2FHV3) | Staphylococcus aureus subsp. aureus USA300 | 50S ribosomal protein L32 |
| 28 | BA (F) | Large ribosomal subunit protein uL5 | polymer | 179 | 20296.6 | 1 | UniProt (Q2FEQ1) | Staphylococcus aureus subsp. aureus USA300 | 50S ribosomal protein L5 |
| 29 | CA (11) | E-site tRNA molecule | polymer | 15 | 4805.0 | 1 | Staphylococcus aureus subsp. aureus USA300 | ||
| 30 | DA (A) | 23S ribosomal RNA | polymer | 2923 | 946822.8 | 1 | Staphylococcus aureus subsp. aureus USA300 | ||
| 31 | EA (Ae) | Small ribosomal subunit protein uS5 | polymer | 166 | 17770.5 | 1 | UniProt (Q2FEQ6) | Staphylococcus aureus subsp. aureus USA300 | 30S ribosomal protein S5 |
| 32 | FA (Af) | Small ribosomal subunit protein bS6 | polymer | 98 | 11613.1 | 1 | UniProt (Q2FJP8) | Staphylococcus aureus subsp. aureus USA300 | 30S ribosomal protein S6 |
| 33 | GA (Ag) | Small ribosomal subunit protein uS7 | polymer | 156 | 17826.6 | 1 | UniProt (Q2FJ94) | Staphylococcus aureus subsp. aureus USA300 | 30S ribosomal protein S7 |
| 34 | HA (Ai) | Small ribosomal subunit protein uS9 | polymer | 132 | 14857.0 | 1 | UniProt (Q2FES2) | Staphylococcus aureus subsp. aureus USA300 | 30S ribosomal protein S9 |
| 35 | IA (Al) | Small ribosomal subunit protein uS12 | polymer | 137 | 15320.9 | 1 | UniProt (Q2FJ95) | Staphylococcus aureus subsp. aureus USA300 | 30S ribosomal protein S12 |
| 36 | JA (Ao) | Small ribosomal subunit protein uS15 | polymer | 89 | 10634.3 | 1 | UniProt (Q2FHG5) | Staphylococcus aureus subsp. aureus USA300 | 30S ribosomal protein S15 |
| 37 | KA (Ap) | Small ribosomal subunit protein bS16 | polymer | 91 | 10253.9 | 1 | UniProt (Q2FHK0) | Staphylococcus aureus subsp. aureus USA300 | 30S ribosomal protein S16 |
| 38 | LA (Aq) | Small ribosomal subunit protein uS17 | polymer | 87 | 10196.9 | 1 | UniProt (Q2FEP8) | Staphylococcus aureus subsp. aureus USA300 | 30S ribosomal protein S17 |
| 39 | MA (Ar) | Small ribosomal subunit protein bS18 | polymer | 80 | 9332.0 | 1 | UniProt (Q2FJP6) | Staphylococcus aureus subsp. aureus USA300 | 30S ribosomal protein S18 |
| 40 | NA (At) | Small ribosomal subunit protein bS20 | polymer | 83 | 9039.5 | 1 | UniProt (Q2FGD8) | Staphylococcus aureus subsp. aureus USA300 | 30S ribosomal protein S20 |
| 41 | OA (Aa) | 16S ribosomal RNA | polymer | 1552 | 502199.7 | 1 | GenBank (1733371935) | Staphylococcus aureus subsp. aureus USA300 | |
| 42 | PA (Aj) | Small ribosomal subunit protein uS10 | polymer | 102 | 11598.5 | 1 | UniProt (Q2FEN8) | Staphylococcus aureus subsp. aureus USA300 | 30S ribosomal protein S10 |
| 43 | QA (Ac) | Small ribosomal subunit protein uS3 | polymer | 217 | 24143.9 | 1 | UniProt (Q2FEP5) | Staphylococcus aureus subsp. aureus USA300 | 30S ribosomal protein S3 |
| 44 | RA (Am) | Small ribosomal subunit protein uS13 | polymer | 121 | 13747.9 | 1 | UniProt (Q2FER3) | Staphylococcus aureus subsp. aureus USA300 | 30S ribosomal protein S13 |
| 45 | SA (Ak) | Small ribosomal subunit protein uS11 | polymer | 129 | 13908.0 | 1 | UniProt (Q2FER4) | Staphylococcus aureus subsp. aureus USA300 | 30S ribosomal protein S11 |
| 46 | TA (Ab) | Small ribosomal subunit protein uS2 | polymer | 255 | 29136.4 | 1 | UniProt (Q2FHI2) | Staphylococcus aureus subsp. aureus USA300 | 30S ribosomal protein S2 |
| 47 | UA (Ah) | Small ribosomal subunit protein uS8 | polymer | 132 | 14854.3 | 1 | UniProt (Q2FEQ3) | Staphylococcus aureus subsp. aureus USA300 | 30S ribosomal protein S8 |
| 48 | VA (Ad) | Small ribosomal subunit protein uS4 | polymer | 200 | 23051.4 | 1 | UniProt (Q2FG18) | Staphylococcus aureus subsp. aureus USA300 | 30S ribosomal protein S4 |
| 49 | WA (An) | Small ribosomal subunit protein uS14B | polymer | 61 | 7317.8 | 1 | UniProt (Q2FEQ2) | Staphylococcus aureus subsp. aureus USA300 | 30S ribosomal protein S14 type Z |
| 50 | XA (As) | Small ribosomal subunit protein uS19 | polymer | 92 | 10639.3 | 1 | UniProt (Q2FEP3) | Staphylococcus aureus subsp. aureus USA300 | 30S ribosomal protein S19 |
| 51 | YA (d) | mRNA molecule | polymer | 19 | 6165.7 | 1 | Staphylococcus aureus subsp. aureus USA300 | ||
| 52 | ZA (8) | P-site tRNA molecule | polymer | 71 | 22913.7 | 1 | Staphylococcus aureus subsp. aureus USA300 | ||
| 53 | AB (9) | A-site tRNA molecule | polymer | 5 | 1554.0 | 1 | Staphylococcus aureus subsp. aureus USA300 | ||
| 54 | BB (13) | Large ribosomal subunit protein bL31B | polymer | 84 | 9737.9 | 1 | UniProt (Q2FF08) | Staphylococcus aureus subsp. aureus USA300 | 50S ribosomal protein L31 type B |
| 55 | CB, DB, GB, VK (1, 4, Z, An) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 56 | AC, AD, AE, AF, AG... (A, Aa, C, D) | MAGNESIUM ION | non-polymer | 24.3 | 231 | Chemie (MG) | |||
| 57 | HB (A) | (3aS,4R,7S,9R,10R,11R,13R,15R,15aR)-1-{4-[4-(3-aminophenyl)-1H-1,2,3-triazol-1-yl]butyl}-4-ethyl-7-fluoro-11-methoxy-3a ,7,9,11,13,15-hexamethyl-2,6,8,14-tetraoxotetradecahydro-2H-oxacyclotetradecino[4,3-d][1,3]oxazol-10-yl 3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranoside | non-polymer | 845.0 | 1 | Chemie (EM1) | |||
| 58 | AI, BI, CI, DI, EI... (A, Aa) | POTASSIUM ION | non-polymer | 39.1 | 18 | Chemie (K) | |||
| 59 | AL, BL, CL, DL, EL... (O, P, R, A, Aa...) | water | water | 18.0 | 621 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 54 |
| Total formula weight | 2171433.3 | |
| Non-Polymers* | Number of molecules | 254 |
| Total formula weight | 7424.9 | |
| All* | Total formula weight | 2178858.2 |
