9QC6

Structure of eIF2B decamer bound to (P)eIF2 alpha and Compound A-(S)

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Translation initiation factor eIF2B subunit alpha	polymer	326	36060.7	2	UniProt (Q14232)	Homo sapiens (human)	eIF2B GDP-GTP exchange factor subunit alpha
2	C, D (C, D)	Translation initiation factor eIF2B subunit beta	polymer	351	39039.5	2	UniProt (P49770)	Homo sapiens (human)	S20I15,S20III15,eIF2B GDP-GTP exchange factor subunit beta
3	E, F (E, F)	Translation initiation factor eIF-2B subunit gamma	polymer	452	50304.2	2	UniProt (Q9NR50)	Homo sapiens (human)	eIF-2B GDP-GTP exchange factor subunit gamma
4	G, H (G, H)	Translation initiation factor eIF-2B subunit delta	polymer	523	57640.2	2	UniProt (Q9UI10)	Homo sapiens (human)	eIF-2B GDP-GTP exchange factor subunit delta
5	I, J (I, J)	Translation initiation factor eIF2B subunit epsilon	polymer	742	82773.1	2	UniProt (Q13144)	Homo sapiens (human)	eIF2B GDP-GTP exchange factor subunit epsilon
6	K (K)	Eukaryotic translation initiation factor 2 subunit 1	polymer	210	24530.9	1	UniProt (P05198)	Homo sapiens (human)	Eukaryotic translation initiation factor 2 subunit alpha,eIF-2-alpha,eIF-2A,eIF-2alpha,eIF2-alpha
7	L (C)	~{N}-[(1~{S})-7-[3-[[ethanoyl(methyl)amino]methyl]phenyl]-5-(trifluoromethyl)-1,2,3,4-tetrahydronaphthalen-1-yl]-2-[[(3~{R},4~{S})-3-fluoranylpiperidin-4-yl]methoxy]-~{N}-methyl-ethanamide	non-polymer		563.6	1	Chemie (A1I5O)

Sequence modifications

A, B: 1 - 305 (UniProt: Q14232)

PDB	External Database	Details
Met -20	-	initiating methionine
Gly -19	-	expression tag
Ser -18	-	expression tag
Ser -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
Ser -10	-	expression tag
Ser -9	-	expression tag
Gly -8	-	expression tag
Leu -7	-	expression tag
Glu -6	-	expression tag
Val -5	-	expression tag
Leu -4	-	expression tag
Phe -3	-	expression tag
Gln -2	-	expression tag
Gly -1	-	expression tag
Pro 0	-	expression tag

I, J: 1 - 721 (UniProt: Q13144)

PDB	External Database	Details
Met -20	-	initiating methionine
Gly -19	-	expression tag
Ser -18	-	expression tag
Ser -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
Ser -10	-	expression tag
Ser -9	-	expression tag
Gly -8	-	expression tag
Leu -7	-	expression tag
Glu -6	-	expression tag
Val -5	-	expression tag
Leu -4	-	expression tag
Phe -3	-	expression tag
Gln -2	-	expression tag
Gly -1	-	expression tag
Pro 0	-	expression tag

K: 0 - 186 (UniProt: P05198)

PDB	External Database	Details
Gly -2	-	expression tag
Ser -1	-	expression tag
Leu 187	-	expression tag
Glu 188	-	expression tag
Arg 189	-	expression tag
Ala 190	-	expression tag
Pro 191	-	expression tag
Gly 192	-	expression tag
Gly 193	-	expression tag
Leu 194	-	expression tag
Asn 195	-	expression tag
Asp 196	-	expression tag
Ile 197	-	expression tag
Phe 198	-	expression tag
Glu 199	-	expression tag
Ala 200	-	expression tag
Gln 201	-	expression tag
Lys 202	-	expression tag
Ile 203	-	expression tag
Glu 204	-	expression tag
Trp 205	-	expression tag
His 206	-	expression tag
Glu 207	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	11
	Total formula weight	556166.3
Non-Polymers*	Number of molecules	1
	Total formula weight	563.6
All*	Total formula weight	556730.0

*Water molecules are not included.