9QBH

HER2/ErbB2 extracellular domain (ECD) from a near full-length construct solubilized in amphipols.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Receptor tyrosine-protein kinase erbB-2,Green fluorescent protein	polymer	1311	146737.2	1	UniProt (P04626) UniProt (P42212) Pfam (PF01030) Pfam (PF00757) Pfam (PF14843) Pfam (PF21314) Pfam (PF07714)	Homo sapiens (human)	Metastatic lymph node gene 19 protein,MLN 19,Proto-oncogene Neu,Proto-oncogene c-ErbB-2,Tyrosine kinase-type cell surface receptor HER2,p185erbB2

Sequence modifications

A: 23 - 1029 (UniProt: P04626)

PDB	External Database	Details
Met -33	-	initiating methionine
Lys -32	-	expression tag
Phe -31	-	expression tag
Leu -30	-	expression tag
Val -29	-	expression tag
Asn -28	-	expression tag
Val -27	-	expression tag
Ala -26	-	expression tag
Leu -25	-	expression tag
Val -24	-	expression tag
Phe -23	-	expression tag
Met -22	-	expression tag
Val -21	-	expression tag
Val -20	-	expression tag
Tyr -19	-	expression tag
Ile -18	-	expression tag
Ser -17	-	expression tag
Tyr -16	-	expression tag
Ile -15	-	expression tag
Tyr -14	-	expression tag
Ala -13	-	expression tag
Asp -12	-	expression tag
Tyr -11	-	expression tag
Lys -10	-	expression tag
Asp -9	-	expression tag
Asp -8	-	expression tag
Asp -7	-	expression tag
Asp -6	-	expression tag
Lys -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag
His 1	-	expression tag
His 2	-	expression tag
His 3	-	expression tag
His 4	-	expression tag
His 5	-	expression tag
Leu 6	-	expression tag
Glu 7	-	expression tag
Val 8	-	expression tag
Leu 9	-	expression tag
Phe 10	-	expression tag
Gln 11	-	expression tag
Gly 12	-	expression tag
Pro 13	-	expression tag
Tyr 14	-	expression tag
Pro 15	-	expression tag
Tyr 16	-	expression tag
Asp 17	-	expression tag
Val 18	-	expression tag
Pro 19	-	expression tag
Asp 20	-	expression tag
Tyr 21	-	expression tag
Ala 22	-	expression tag
Ser 789	Cys 789	engineered mutation
Ser 805	Cys 805	engineered mutation
Ser 965	Cys 965	engineered mutation
Leu 1030	-	linker
Glu 1031	-	linker
Val 1032	-	linker
Leu 1033	-	linker
Phe 1034	-	linker
Gln 1035	-	linker
Gly 1036	-	linker
Pro 1037	-	linker
Gly 1038	-	linker
Ser 1039	-	linker

A: 1040 - 1277 (UniProt: P42212)

PDB	External Database	Details
Arg 1069	Ser 30	conflict
Asn 1078	Tyr 39	conflict
Leu 1103	Phe 64	conflict
Thr 1104	Ser 65	conflict
Arg 1119	Gln 80	conflict
Ser 1138	Phe 99	conflict
Thr 1144	Asn 105	conflict
Phe 1184	Tyr 145	conflict
Thr 1192	Met 153	conflict
Ala 1202	Val 163	conflict
Val 1210	Ile 171	conflict
Val 1245	Ala 206	conflict

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	146737.2
All*	Total formula weight	146737.2

*Water molecules are not included.