9QAV

Human angiotensin-1 converting enzyme N-domain in complex with enalaprilat

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Angiotensin-converting enzyme, soluble form	polymer	609	70366.1	2	UniProt (P12821) Pfam (PF01401)	Homo sapiens (human)
2	C, F (D, F)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose	branched		570.5	2	In PDB GlyTouCan (G21290RB)
3	D, E (C, E)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	2	In PDB GlyTouCan (G42666HT)
4	G, T (A, B)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
5	H, U, V (A, B)	TETRAETHYLENE GLYCOL	non-polymer		194.2	3	Chemie (PG4)
6	I, K, N, P (A)	DI(HYDROXYETHYL)ETHER	non-polymer		106.1	4	Chemie (PEG)
7	J, L (A)	TRIETHYLENE GLYCOL	non-polymer		150.2	2	Chemie (PGE)
8	AA, M, W, X, Y... (B, A)	1,2-ETHANEDIOL	non-polymer		62.1	6	Chemie (EDO)
9	BA, O (B, A)	1-((2S)-2-{[(1S)-1-CARBOXY-3-PHENYLPROPYL]AMINO}PROPANOYL)-L-PROLINE	non-polymer		348.4	2	Chemie (EAL)
10	CA, Q (B, A)	CHLORIDE ION	non-polymer		35.5	2	Chemie (CL)
11	R, S (B)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)
12	DA (B)	CALCIUM ION	non-polymer		40.1	1	Chemie (CA)
13	EA, FA (A, B)	water	water		18.0	174	Chemie (HOH)

Sequence modifications

A, B: 1 - 609 (UniProt: P12821)

PDB	External Database	Details
Gln 9	Asn 38	engineered mutation
Gln 25	Asn 54	engineered mutation
Gln 82	Asn 111	engineered mutation
Gln 117	Asn 146	engineered mutation
Gln 289	Asn 318	engineered mutation
Arg 545	Gln 574	engineered mutation
Leu 576	Pro 605	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	140732.2
Branched	Number of molecules	4
	Total formula weight	1989.9
Non-Polymers*	Number of molecules	24
	Total formula weight	3060.9
All*	Total formula weight	145783.0

*Water molecules are not included.