9QAU

Human angiotensin-1 converting enzyme N-domain in complex with perindoprilat

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Angiotensin-converting enzyme, soluble form	polymer	608	70178.9	2	UniProt (P12821) Pfam (PF01401)	Homo sapiens (human)
2	C (G)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose	branched		570.5	1	In PDB GlyTouCan (G21290RB)
3	D (F)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	1	In PDB GlyTouCan (G42666HT)
4	E, N (A, B)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
5	F, G, O, X (A, B)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	4	Chemie (NAG)
6	H, R (A, B)	TETRAETHYLENE GLYCOL	non-polymer		194.2	2	Chemie (PG4)
7	I, T (A, B)	1,2-ETHANEDIOL	non-polymer		62.1	2	Chemie (EDO)
8	J, Q (A, B)	TRIETHYLENE GLYCOL	non-polymer		150.2	2	Chemie (PGE)
9	K, P, S, U (A, B)	DI(HYDROXYETHYL)ETHER	non-polymer		106.1	4	Chemie (PEG)
10	L, V (A, B)	PERINDOPRILAT	non-polymer		340.4	2	Chemie (X94)
11	M, W (A, B)	CHLORIDE ION	non-polymer		35.5	2	Chemie (CL)
12	Y, Z (A, B)	water	water		18.0	618	Chemie (HOH)

Sequence modifications

A, B: 1 - 608 (UniProt: P12821)

PDB	External Database	Details
Gln 9	Asn 38	engineered mutation
Gln 25	Asn 54	engineered mutation
Gln 82	Asn 111	engineered mutation
Gln 117	Asn 146	engineered mutation
Gln 289	Asn 318	engineered mutation
Ala 341	Lys 370	engineered mutation
Arg 545	Gln 574	engineered mutation
Leu 576	Pro 605	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	140357.8
Branched	Number of molecules	2
	Total formula weight	994.9
Non-Polymers*	Number of molecules	20
	Total formula weight	3004.8
All*	Total formula weight	144357.5

*Water molecules are not included.