9QAS
Human angiotensin-1 converting enzyme N-domain in complex with trandolaprilat
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Angiotensin-converting enzyme, soluble form | polymer | 609 | 70366.1 | 2 | UniProt (P12821) Pfam (PF01401) | Homo sapiens (human) | |
| 2 | C (F) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 732.7 | 1 | In PDB GlyTouCan (G32152BH) | |||
| 3 | D, F (G, I) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 570.5 | 2 | In PDB GlyTouCan (G21290RB) | |||
| 4 | E (H) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 5 | G (J) | alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 367.3 | 1 | In PDB GlyTouCan (G86851RC) | |||
| 6 | AA, H (B, A) | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 2 | Chemie (PG4) PubChem (8200) | |||
| 7 | I (A) | ACETATE ION | non-polymer | 59.0 | 1 | Chemie (ACT) PubChem (175) | |||
| 8 | BA, J, Q, X, Y (B, A) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 5 | Chemie (PEG) PubChem (8117) | |||
| 9 | K, Z (A, B) | TRANDOLAPRILAT | non-polymer | 402.5 | 2 | Chemie (X93) PubChem (18654872) PubChem (44385538) PubChem (45359124) PubChem (128549) PubChem (66608625) PubChem (67788183) PubChem (67788187) PubChem (69491076) PubChem (69491081) PubChem (70044540) PubChem (70074951) PubChem (70554069) PubChem (70692645) PubChem (69568154) PubChem (5464097) PubChem (118719308) PubChem (9978465) PubChem (13069293) PubChem (172108640) PubChem (126969207) PubChem (133543001) PubChem (140144050) PubChem (168312406) | |||
| 10 | L, M, N, O, R (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 5 | Chemie (EDO) | |||
| 11 | P, W (A, B) | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 2 | Chemie (PGE) | |||
| 12 | CA, S (B, A) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 13 | DA, T (B, A) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) PubChem (312) | |||
| 14 | EA, U, V (B, A) | CALCIUM ION | non-polymer | 40.1 | 3 | Chemie (CA) PubChem (271) | |||
| 15 | FA, GA (A, B) | water | water | 18.0 | 727 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 609 (UniProt: P12821)
| PDB | External Database | Details |
|---|---|---|
| Gln 9 | Asn 38 | engineered mutation |
| Gln 25 | Asn 54 | engineered mutation |
| Gln 82 | Asn 111 | engineered mutation |
| Gln 117 | Asn 146 | engineered mutation |
| Gln 289 | Asn 318 | engineered mutation |
| Arg 545 | Gln 574 | engineered mutation |
| Leu 576 | Pro 605 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 140732.2 | |
| Branched | Number of molecules | 5 |
| Total formula weight | 2665.5 | |
| Non-Polymers* | Number of molecules | 24 |
| Total formula weight | 2715.7 | |
| All* | Total formula weight | 146113.4 |
