9QAD
Crystal structure of the SMARCA2 bromodomain bound to a tricyclic pyrimidoindolone inhibitor (compound 17)
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Probable global transcription activator SNF2L2 | polymer | 123 | 14380.5 | 3 | UniProt (P51531) Pfam (PF00439) | Homo sapiens (human) | ATP-dependent helicase SMARCA2,BRG1-associated factor 190B,BAF190B,Protein brahma homolog,hBRM,SNF2-alpha,SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 |
| 2 | D, F, H (A, B, C) | 5-oxidanyl-2-(phenylmethyl)-1,9-dihydropyrimido[4,5-b]indol-4-one | non-polymer | 291.3 | 3 | Chemie (A1I45) | |||
| 3 | E, G, I (A, B, C) | ZINC ION | non-polymer | 65.4 | 3 | Chemie (ZN) | |||
| 4 | J, K, L (A, B, C) | water | water | 18.0 | 40 | Chemie (HOH) |
Sequence modifications
A, B, C: 1373 - 1511 (UniProt: P51531)
| PDB | External Database | Details |
|---|---|---|
| Ser 1371 | - | expression tag |
| Met 1372 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 43141.6 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1070.1 | |
| All* | Total formula weight | 44211.8 |
