9Q89
Crystal structure of the human METTL3-METTL14 in complex with small molecule inhibitor Compound 13
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | N6-adenosine-methyltransferase catalytic subunit | polymer | 213 | 24527.2 | 1 | UniProt (Q86U44) Pfam (PF05063) | Homo sapiens (human) | Methyltransferase-like protein 3,hMETTL3,N6-adenosine-methyltransferase 70 kDa subunit,MT-A70 |
| 2 | B (B) | N(6)-adenosine-methyltransferase non-catalytic subunit METTL14 | polymer | 280 | 32550.0 | 1 | UniProt (Q9HCE5) Pfam (PF05063) | Homo sapiens (human) | Methyltransferase-like protein 14,hMETTL14 |
| 3 | C (A) | (3~{R})-~{N}-(cyclopropylmethyl)-1-[6-[3-[4-(6-pyrrolidin-1-ylpyrazin-2-yl)-1,2,3-triazol-1-yl]oxetan-3-yl]pyridin-3-yl]piperidin-3-amine | non-polymer | 501.6 | 1 | Chemie (A1I4J) PubChem (172105885) | |||
| 4 | D, E, F, G (A, B) | CALCIUM ION | non-polymer | 40.1 | 4 | Chemie (CA) PubChem (271) | |||
| 5 | H, I (A, B) | water | water | 18.0 | 246 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 57077.2 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 661.9 | |
| All* | Total formula weight | 57739.1 |
