9Q7X
Crystal structure of the MKP5 loop mutant N448A in complex with the allosteric inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Dual specificity protein phosphatase 10 | polymer | 148 | 17023.6 | 6 | UniProt (Q9Y6W6) Pfam (PF00782) | Homo sapiens (human) | Mitogen-activated protein kinase phosphatase 5,MAP kinase phosphatase 5,MKP-5 |
| 2 | G, H, I, J, K... (A, B, C, D, E...) | 3,3-dimethyl-1-{[9-(methylsulfanyl)-5,6-dihydrothieno[3,4-h]quinazolin-2-yl]sulfanyl}butan-2-one | non-polymer | 364.5 | 6 | Chemie (CJA) |
Sequence modifications
A, B, C, D, E, F: 320 - 466 (UniProt: Q9Y6W6)
| PDB | External Database | Details |
|---|---|---|
| Met 319 | - | initiating methionine |
| Ala 448 | Asn 448 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 102141.4 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 2187.3 | |
| All* | Total formula weight | 104328.6 |
