9Q6X
Human prolyl endopeptidase (PREP) - complex with KT-2-186
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (C, A, B) | Prolyl endopeptidase | polymer | 711 | 80851.4 | 3 | UniProt (P48147) Pfam (PF02897) Pfam (PF00326) | Homo sapiens (human) | PE,Post-proline cleaving enzyme |
| 2 | AA, D, DA, EA, HB... (C, B, A) | THIOCYANATE ION | non-polymer | 58.1 | 17 | Chemie (SCN) | |||
| 3 | CA, E, I, KB, L... (C, B, A) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 10 | Chemie (PEG) | |||
| 4 | BB, CB, F, FB, G... (A, C, B) | GLYCEROL | non-polymer | 92.1 | 27 | Chemie (GOL) | |||
| 5 | BA, MB, X, XA, Z (C, B, A) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 5 | Chemie (DMS) | |||
| 6 | AB, FA, PB (A, C, B) | 4-chloro-3-methyl-N-[2-oxo-2-(pyrrolidin-1-yl)ethyl]-1-[2-(pyridin-3-yl)ethyl]-1H-pyrazolo[3,4-b]pyridine-5-carboxamide | non-polymer | 426.9 | 3 | Chemie (A1CQ1) | |||
| 7 | EB, LA (B, A) | 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | non-polymer | 282.3 | 2 | Chemie (B3P) | |||
| 8 | DB (A) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 9 | QB, RB, SB (C, A, B) | water | water | 18.0 | 1569 | Chemie (HOH) |
Sequence modifications
C, A, B: 1 - 710 (UniProt: P48147)
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 242554.1 | |
| Non-Polymers* | Number of molecules | 65 |
| Total formula weight | 6794.2 | |
| All* | Total formula weight | 249348.3 |
