9Q6G
PYCR2 complexed with NAD+ and (2S)-2-hydroxy-3,3-dimethylbutanoic acid
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E (A, B, C, D, E) | Pyrroline-5-carboxylate reductase 2 | polymer | 316 | 33621.8 | 5 | UniProt (Q96C36) Pfam (PF03807) Pfam (PF14748) | Homo sapiens (human) | P5C reductase 2,P5CR 2 |
| 2 | F, M (A, E) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 3 | G, I, J, K, N (A, B, C, D, E) | NICOTINAMIDE-ADENINE-DINUCLEOTIDE | non-polymer | 663.4 | 5 | Chemie (NAD) | |||
| 4 | H, L (B, E) | (2S)-2-hydroxy-3,3-dimethylbutanoic acid | non-polymer | 132.2 | 2 | Chemie (G8I) PubChem (11097105) | |||
| 5 | O, P, Q (A, B, E) | water | water | 18.0 | 9 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E: 1 - 294 (UniProt: Q96C36)
| PDB | External Database | Details |
|---|---|---|
| Met -21 | - | initiating methionine |
| His -20 | - | expression tag |
| His -19 | - | expression tag |
| His -18 | - | expression tag |
| His -17 | - | expression tag |
| His -16 | - | expression tag |
| His -15 | - | expression tag |
| Ser -14 | - | expression tag |
| Ser -13 | - | expression tag |
| Gly -12 | - | expression tag |
| Val -11 | - | expression tag |
| Asp -10 | - | expression tag |
| Leu -9 | - | expression tag |
| Gly -8 | - | expression tag |
| Thr -7 | - | expression tag |
| Glu -6 | - | expression tag |
| Asn -5 | - | expression tag |
| Leu -4 | - | expression tag |
| Tyr -3 | - | expression tag |
| Phe -2 | - | expression tag |
| Gln -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Gln 276 | Lys 276 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 168109.0 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 3773.6 | |
| All* | Total formula weight | 171882.6 |
