9Q4U
Structure of rat neuronal nitric oxide synthase R349A mutant heme domain bound with 6-((2,3-difluoro-5-(2-(3-fluoroazetidin-1-yl)ethyl)phenoxy)methyl)-4-methylpyridin-2-amine
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Nitric oxide synthase, brain | polymer | 422 | 48726.4 | 1 | UniProt (P29476) Pfam (PF02898) | Rattus norvegicus (Norway rat) | BNOS,Constitutive NOS,NC-NOS,NOS type I,Neuronal NOS,nNOS,Peptidyl-cysteine S-nitrosylase NOS1 |
| 2 | B (A) | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 1 | Chemie (HEM) | |||
| 3 | C (A) | 5,6,7,8-TETRAHYDROBIOPTERIN | non-polymer | 241.2 | 1 | Chemie (H4B) | |||
| 4 | D (A) | 6-({2,3-difluoro-5-[2-(3-fluoroazetidin-1-yl)ethyl]phenoxy}methyl)-4-methylpyridin-2-amine | non-polymer | 351.4 | 1 | Chemie (A1CN7) | |||
| 5 | E (A) | ACETATE ION | non-polymer | 59.0 | 1 | Chemie (ACT) | |||
| 6 | F (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 7 | G (A) | water | water | 18.0 | 40 | Chemie (HOH) |
Sequence modifications
A: 297 - 718 (UniProt: P29476)
| PDB | External Database | Details |
|---|---|---|
| Ala 349 | Arg 349 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 48726.4 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1333.6 | |
| All* | Total formula weight | 50060.0 |
