9Q3X
The CryoEM structure of Rhesus macaque 1G3 and PGT121 Fabs in complex with BG505 SOSIP.664
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, G, M (G, A, I) | BG505 SOSIP.664 gp120 | polymer | 481 | 54064.3 | 3 | UniProt (Q2N0S5) | Human immunodeficiency virus 1 | |
| 2 | B, H, N (B, C, J) | BG505 SOSIP.664 gp41 | polymer | 153 | 17146.5 | 3 | UniProt (Q2N0S5) | Human immunodeficiency virus 1 | |
| 3 | C, I, O (H, D, K) | 1G3 Fab heavy chain | polymer | 115 | 12346.7 | 3 | Macaca mulatta (Rhesus macaque) | ||
| 4 | D, J, P (L, E, M) | 1G3 Fab light chain | polymer | 106 | 11728.1 | 3 | Macaca mulatta (Rhesus macaque) | ||
| 5 | E, K, Q (h, d, k) | PGT121 Fab heavy chain | polymer | 235 | 25169.2 | 3 | Homo sapiens | ||
| 6 | F, L, R (l, e, m) | PGT121 Fab light chain | polymer | 213 | 22869.3 | 3 | Homo sapiens | ||
| 7 | AA, AB, BB, CA, DA... (o, 1, 2, q, r...) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 24 | In PDB GlyTouCan (G42666HT) | |||
| 8 | HA, TA, V (v, U, f) | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 3 | In PDB GlyTouCan (G81315DD) | |||
| 9 | KA, WA, Y (y, X, j) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 3 | In PDB GlyTouCan (G15407YE) | |||
| 10 | LA, XA, Z (z, Y, n) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 3 | In PDB GlyTouCan (G22768VO) | |||
| 11 | BA, NA, ZA (p, O, 0) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1559.4 | 3 | In PDB GlyTouCan (G68668TB) | |||
| 12 | CB, DB, EB, FB, GB... (G, B, A, C, I...) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 24 | Chemie (NAG) PubChem (24139) |
Sequence modifications
G, A, I: 31 - 511 (UniProt: Q2N0S5)
B, C, J: 512 - 664 (UniProt: Q2N0S5)
| PDB | External Database | Details |
|---|---|---|
| Asn 332 | Thr 330 | engineered mutation |
| Cys 501 | Ala 498 | engineered mutation |
| Arg 509 | Glu 506 | engineered mutation |
| Arg 510 | Lys 507 | engineered mutation |
| Arg 512 | - | insertion |
| Arg 513 | - | insertion |
| PDB | External Database | Details |
|---|---|---|
| Pro 559 | Ile 556 | engineered mutation |
| Cys 605 | Thr 602 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 18 |
| Total formula weight | 429972.3 | |
| Branched | Number of molecules | 36 |
| Total formula weight | 21601.9 | |
| Non-Polymers* | Number of molecules | 24 |
| Total formula weight | 5309.0 | |
| All* | Total formula weight | 456883.2 |
