9Q3F
Structure of neurodevelopmental mutant AGO1 F180del in complex with guide RNA
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Protein argonaute-1 | polymer | 870 | 98733.7 | 1 | UniProt (Q9UL18) Pfam (PF16486) Pfam (PF08699) Pfam (PF02170) Pfam (PF16488) Pfam (PF16487) Pfam (PF02171) | Homo sapiens (human) | Argonaute1,hAgo1,Argonaute RISC catalytic component 1,Eukaryotic translation initiation factor 2C 1,eIF-2C 1,eIF2C 1,Putative RNA-binding protein Q99 |
| 2 | B (B) | Non-homogenous guide RNA | polymer | 8 | 2588.7 | 1 | Trichoplusia ni (cabbage looper) |
Sequence modifications
A: 1 - 856 (UniProt: Q9UL18)
| PDB | External Database | Details |
|---|---|---|
| Gly -13 | - | expression tag |
| Ala -12 | - | expression tag |
| Met -11 | - | expression tag |
| Gly -10 | - | expression tag |
| Ser -9 | - | expression tag |
| Met -8 | - | expression tag |
| Asp -7 | - | expression tag |
| Tyr -6 | - | expression tag |
| Lys -5 | - | expression tag |
| Asp -4 | - | expression tag |
| Asp -3 | - | expression tag |
| Asp -2 | - | expression tag |
| Asp -1 | - | expression tag |
| Lys 0 | - | expression tag |
| - | Phe 179 | deletion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 101322.4 | |
| All* | Total formula weight | 101322.4 |
