9Q26
Structure of the Measles virus Fusion glycoprotein ectodomain in complex with two neutralizing antibodies 4F09 and 3A12
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, E, I (D, H, L) | 3A12 Fab Heavy chain | polymer | 252 | 26836.1 | 3 | Homo sapiens | ||
| 2 | B, F, J (E, I, M) | 3A12 Fab Light chain | polymer | 236 | 25989.1 | 3 | Homo sapiens | ||
| 3 | C, G, K (F, J, N) | 4F09 Fab Heavy chain | polymer | 259 | 27843.1 | 3 | Homo sapiens | ||
| 4 | D, H, L (G, K, O) | 4F09 Fab Light Chain | polymer | 236 | 26008.1 | 3 | Homo sapiens | ||
| 5 | M, O, Q (a, b, c) | Fusion glycoprotein F2 | polymer | 112 | 12498.8 | 3 | UniProt (Q786F3) | Measles morbillivirus | |
| 6 | N, P, R (A, B, C) | Fusion glycoprotein F1 | polymer | 420 | 44898.8 | 3 | UniProt (Q786F3) | Measles morbillivirus | |
| 7 | S, Y (P, V) | alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 2 | In PDB GlyTouCan (G22573RC) | |||
| 8 | T, V, Z (Q, S, W) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 570.5 | 3 | In PDB GlyTouCan (G21290RB) | |||
| 9 | AA, U, W (X, R, T) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 3 | In PDB GlyTouCan (G42666HT) | |||
| 10 | X (U) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G15407YE) | |||
| 11 | BA (F) | alpha-D-mannopyranose | non-polymer | 180.2 | 1 | Chemie (MAN) PubChem (185698) |
Sequence modifications
A, B, C: 113 - 495 (UniProt: Q786F3)
| PDB | External Database | Details |
|---|---|---|
| Gly 170 | Glu 170 | engineered mutation |
| Gly 455 | Glu 455 | engineered mutation |
| Gly 496 | - | expression tag |
| Val 497 | - | expression tag |
| Asp 498 | - | expression tag |
| Asp 499 | - | expression tag |
| Asp 500 | - | expression tag |
| Asp 501 | - | expression tag |
| Lys 502 | - | expression tag |
| Ala 503 | - | expression tag |
| Gly 504 | - | expression tag |
| Trp 505 | - | expression tag |
| Ser 506 | - | expression tag |
| His 507 | - | expression tag |
| Pro 508 | - | expression tag |
| Gln 509 | - | expression tag |
| Phe 510 | - | expression tag |
| Glu 511 | - | expression tag |
| Lys 512 | - | expression tag |
| Gly 513 | - | expression tag |
| Gly 514 | - | expression tag |
| Gly 515 | - | expression tag |
| Ser 516 | - | expression tag |
| Gly 517 | - | expression tag |
| Gly 518 | - | expression tag |
| Gly 519 | - | expression tag |
| Ser 520 | - | expression tag |
| Gly 521 | - | expression tag |
| Gly 522 | - | expression tag |
| Gly 523 | - | expression tag |
| Ser 524 | - | expression tag |
| Trp 525 | - | expression tag |
| Ser 526 | - | expression tag |
| His 527 | - | expression tag |
| Pro 528 | - | expression tag |
| Gln 529 | - | expression tag |
| Phe 530 | - | expression tag |
| Glu 531 | - | expression tag |
| Lys 532 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 18 |
| Total formula weight | 492221.9 | |
| Branched | Number of molecules | 9 |
| Total formula weight | 5068.7 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 180.2 | |
| All* | Total formula weight | 497470.8 |
