9Q22
Crystal structure of ternary complex Helios-ZF2:I-19:CRBN:DDB1
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | DNA damage-binding protein 1 | polymer | 856 | 95773.7 | 1 | UniProt (Q16531) Pfam (PF10433) Pfam (PF03178) | Homo sapiens (human) | DDB p127 subunit,DNA damage-binding protein a,DDBa,Damage-specific DNA-binding protein 1,HBV X-associated protein 1,XAP-1,UV-damaged DNA-binding factor,UV-damaged DNA-binding protein 1,UV-DDB 1,XPE-binding factor,XPE-BF,Xeroderma pigmentosum group E-complementing protein,XPCe |
| 2 | B (B) | Protein cereblon | polymer | 426 | 48976.1 | 1 | UniProt (Q96SW2) Pfam (PF02190) Pfam (PF03226) | Homo sapiens (human) | |
| 3 | C (C) | Zinc finger protein Helios | polymer | 31 | 3431.9 | 1 | UniProt (Q9UKS7) Pfam (PF00096) | Homo sapiens (human) | Ikaros family zinc finger protein 2 |
| 4 | D (B) | (3S)-3-[5-(1-benzyl-4-hydroxypiperidin-4-yl)-1-oxo-1,3-dihydro-2H-isoindol-2-yl]piperidine-2,6-dione | non-polymer | 433.5 | 1 | Chemie (A1CNP) | |||
| 5 | E, F (B, C) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) |
Sequence modifications
A: 1 - 381 (UniProt: Q16531)
A: 706 - 1140 (UniProt: Q16531)
B: 41 - 442 (UniProt: Q96SW2)
C: 135 - 163 (UniProt: Q9UKS7)
| PDB | External Database | Details |
|---|---|---|
| Met -19 | - | expression tag |
| His -18 | - | expression tag |
| His -17 | - | expression tag |
| His -16 | - | expression tag |
| His -15 | - | expression tag |
| His -14 | - | expression tag |
| His -13 | - | expression tag |
| Val -12 | - | expression tag |
| Asp -11 | - | expression tag |
| Glu -10 | - | expression tag |
| Glu -9 | - | expression tag |
| Asn -8 | - | expression tag |
| Leu -7 | - | expression tag |
| Tyr -6 | - | expression tag |
| Phe -5 | - | expression tag |
| Gln -4 | - | expression tag |
| Gly -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Arg 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Phe 382 | - | linker |
| Lys 383 | - | linker |
| Glu 384 | - | linker |
| Gly 385 | - | linker |
| Ser 386 | - | linker |
| Leu 387 | - | linker |
| Arg 388 | - | linker |
| Ile 389 | - | linker |
| Ile 390 | - | linker |
| Arg 391 | - | linker |
| Asn 392 | - | linker |
| Gly 393 | - | linker |
| Ile 698 | - | linker |
| Gly 699 | - | linker |
| Gly 700 | - | linker |
| Asn 701 | - | linker |
| Gly 702 | - | linker |
| Asn 703 | - | linker |
| Ser 704 | - | linker |
| Gly 705 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Met 17 | - | expression tag |
| Asp 18 | - | expression tag |
| Trp 19 | - | expression tag |
| Ser 20 | - | expression tag |
| His 21 | - | expression tag |
| Pro 22 | - | expression tag |
| Gln 23 | - | expression tag |
| Phe 24 | - | expression tag |
| Glu 25 | - | expression tag |
| Lys 26 | - | expression tag |
| Ser 27 | - | expression tag |
| Ala 28 | - | expression tag |
| Val 29 | - | expression tag |
| Asp 30 | - | expression tag |
| Glu 31 | - | expression tag |
| Asn 32 | - | expression tag |
| Leu 33 | - | expression tag |
| Tyr 34 | - | expression tag |
| Phe 35 | - | expression tag |
| Gln 36 | - | expression tag |
| Gly 37 | - | expression tag |
| Gly 38 | - | expression tag |
| Gly 39 | - | expression tag |
| Arg 40 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 133 | - | expression tag |
| Ser 134 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 148181.7 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 564.3 | |
| All* | Total formula weight | 148746.0 |
