9Q1N

Crystal structure of human TEAD2-Yap binding domain covalently bound to an allosteric regulator

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (B, A)	Transcriptional enhancer factor TEF-4	polymer	234	26627.2	2	UniProt (Q15562) Pfam (PF17725)	Homo sapiens (human)	TEA domain family member 2,TEAD-2
2	C, D (B, A)	1-{4-[4-(trifluoromethyl)anilino]-1,3-dihydro-2H-isoindol-2-yl}propan-1-one	non-polymer		334.3	2	Chemie (EI2)
3	E, F (B, A)	water	water		18.0	55	Chemie (HOH)

Sequence modifications

B, A: 217 - 447 (UniProt: Q15562)

PDB	External Database	Details
Gly 214	-	expression tag
His 215	-	expression tag
Met 216	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	53254.3
Non-Polymers*	Number of molecules	2
	Total formula weight	668.7
All*	Total formula weight	53923.0

*Water molecules are not included.