9Q1M
Crystal structure of human TEAD2 Yap binding domain covalently bound to an allosteric regulator
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (B, A) | Transcriptional enhancer factor TEF-4 | polymer | 234 | 26627.2 | 2 | UniProt (Q15562) Pfam (PF17725) | Homo sapiens (human) | TEA domain family member 2,TEAD-2 |
| 2 | C, D (B, A) | 1-{4-[3-(trifluoromethyl)anilino]-2H-isoindol-2-yl}propan-1-one | non-polymer | 332.3 | 2 | Chemie (IU8) | |||
| 3 | E, F (B, A) | water | water | 18.0 | 27 | Chemie (HOH) |
Sequence modifications
B, A: 217 - 447 (UniProt: Q15562)
| PDB | External Database | Details |
|---|---|---|
| Gly 214 | - | expression tag |
| His 215 | - | expression tag |
| Met 216 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 53254.3 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 664.6 | |
| All* | Total formula weight | 53919.0 |
