9Q1J
Cryo-EM structure of SARS-CoV-2 nsp10-nsp14 E191A mutant-T20P14-R complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, G, I (A, C, G, I) | Non-structural protein 10 | polymer | 139 | 14802.9 | 4 | UniProt (P0DTD1) Pfam (PF09401) | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV SARS-CoV-2) | nsp10,Growth factor-like peptide,GFL |
| 2 | B, D, H, J (B, D, H, J) | Proofreading exoribonuclease | polymer | 527 | 59829.4 | 4 | UniProt (P0DTD1) Pfam (PF06471) | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV SARS-CoV-2) | ExoN,Guanine-N7 methyltransferase,Non-structural protein 14,nsp14 |
| 3 | E, K (E, K) | T20P14-R RNA | polymer | 39 | 12541.5 | 2 | Severe acute respiratory syndrome coronavirus 2 | ||
| 4 | F, L (F, L) | RNA (5'-R(*A*UP*UP*CP*CP*CP*C)-3') | polymer | 7 | 2117.3 | 2 | Severe acute respiratory syndrome coronavirus 2 | ||
| 5 | BA, CA, DA, EA, FA... (H, I, J, A, B...) | ZINC ION | non-polymer | 65.4 | 20 | Chemie (ZN) | |||
| 6 | AA, GA, O, U (H, J, B, D) | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) |
Sequence modifications
B, D, H, J: 1 - 527 (UniProt: P0DTD1)
| PDB | External Database | Details |
|---|---|---|
| Ala 191 | Glu 6116 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 327847.0 | |
| Non-Polymers* | Number of molecules | 24 |
| Total formula weight | 1405.4 | |
| All* | Total formula weight | 329252.4 |
