9PZ0

SARS-CoV-2 core polymerase complex with two UTP incorporation

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	RNA-directed RNA polymerase nsp12	polymer	964	110424.9	1	UniProt (P0DTD1) Pfam (PF06478) Pfam (PF00680)	Severe acute respiratory syndrome coronavirus 2	Pol,RdRp,Non-structural protein 12,nsp12
2	B, D (B, D)	Non-structural protein 8	polymer	199	21960.1	2	UniProt (P0DTD1) Pfam (PF08717)	Severe acute respiratory syndrome coronavirus 2	nsp8
3	C (C)	Non-structural protein 7	polymer	84	9305.9	1	UniProt (P0DTD1) Pfam (PF08716)	Severe acute respiratory syndrome coronavirus 2	nsp7
4	E (P)	Primer RNA	polymer	31	9793.9	1		Severe acute respiratory syndrome coronavirus 2
5	F (T)	Template RNA	polymer	38	12088.1	1		Severe acute respiratory syndrome coronavirus 2
6	G, H (A)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)

Sequence modifications

A: 1 - 932 (UniProt: P0DTD1)

PDB	External Database	Details
Met -1	-	initiating methionine
Gly 0	-	expression tag
Glu 933	-	expression tag
Asn 934	-	expression tag
Leu 935	-	expression tag
Tyr 936	-	expression tag
Phe 937	-	expression tag
Gln 938	-	expression tag
Gly 939	-	expression tag
Ser 940	-	expression tag
Trp 941	-	expression tag
Ser 942	-	expression tag
His 943	-	expression tag
Pro 944	-	expression tag
Gln 945	-	expression tag
Phe 946	-	expression tag
Glu 947	-	expression tag
Lys 948	-	expression tag
Gly 949	-	expression tag
Gly 950	-	expression tag
Ser 951	-	expression tag
Gly 952	-	expression tag
Ser 953	-	expression tag
Ser 954	-	expression tag
Trp 955	-	expression tag
Ser 956	-	expression tag
His 957	-	expression tag
Pro 958	-	expression tag
Gln 959	-	expression tag
Phe 960	-	expression tag
Glu 961	-	expression tag
Lys 962	-	expression tag

B, D: 1 - 198 (UniProt: P0DTD1)

PDB	External Database	Details
Gly 0	-	expression tag

C: 1 - 83 (UniProt: P0DTD1)

PDB	External Database	Details
Gly 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	185532.9
Non-Polymers*	Number of molecules	2
	Total formula weight	130.8
All*	Total formula weight	185663.7

*Water molecules are not included.