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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9PY4

Primed-state loperamide-mu opioid receptor-Gi GDPbS complex (rebound)

This is a non-PDB format compatible entry.
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)		Guanine nucleotide-binding protein G(i) subunit alpha-1polymer35440415.01UniProt (P63096)
Pfam (PF00503)		Homo sapiens (human)Adenylate cyclase-inhibiting G alpha protein
2B
(B)		Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1polymer36139839.51UniProt (P62873)
Pfam (PF25391)		Homo sapiens (human)Transducin beta chain 1
3C
(C)		Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2polymer717861.11UniProt (P59768)
Pfam (PF00631)		Homo sapiens (human)G gamma-I
4D
(R)		Cytochrome b-562/Mu-type opioid receptor chimera protein,Mu-type opioid receptorpolymer62269540.41UniProt (P0ABE7)
UniProt (P35372)
Pfam (PF00001)		Escherichia coli
5E
(A)		5'-O-[(R)-hydroxy(thiophosphonooxy)phosphoryl]guanosinenon-polymer459.31Chemie (VSN)
PubChem (135583303)
PubChem (137258001)
PubChem (135410865)
PubChem (135457564)
PubChem (135487899)
PubChem (135707695)
PubChem (136663988)
PubChem (137218939)
PubChem (155817661)
PubChem (162290140)
PubChem (163901066)
6F, G
(R)		CHOLESTEROLnon-polymer386.72Chemie (CLR)
PubChem (304)
PubChem (191463)
PubChem (368063)
PubChem (369319)
PubChem (638019)
PubChem (1549081)
PubChem (1553803)
PubChem (5283629)
PubChem (5284644)
PubChem (5315842)
PubChem (6419195)
PubChem (6994560)
PubChem (7055705)
PubChem (7055706)
PubChem (7059398)
PubChem (7059400)
PubChem (7059635)
PubChem (7103033)
PubChem (7182477)
PubChem (7182478)
PubChem (9909206)
PubChem (10045721)
PubChem (71168115)
PubChem (10134774)
PubChem (10293553)
PubChem (71173031)
PubChem (11003580)
PubChem (11025495)
PubChem (11058155)
PubChem (11463329)
PubChem (11868624)
PubChem (11868625)
PubChem (11869366)
PubChem (11869367)
PubChem (11869368)
PubChem (11869369)
PubChem (12120344)
PubChem (12156156)
PubChem (12303135)
PubChem (12303148)
PubChem (12303156)
PubChem (12303159)
PubChem (12303160)
PubChem (16219173)
PubChem (16758052)
PubChem (40477506)
PubChem (40557614)
PubChem (42579431)
PubChem (42579432)
PubChem (176980071)
PubChem (45044259)
PubChem (18640088)
PubChem (1715243)
PubChem (1715244)
PubChem (23423981)
PubChem (49853509)
PubChem (44654663)
PubChem (46937002)
PubChem (59274407)
PubChem (50990013)
PubChem (68311425)
PubChem (68311398)
PubChem (143173313)
PubChem (177156123)
PubChem (5997)
PubChem (1551269)
PubChem (90070115)
PubChem (52934537)
PubChem (117965027)
PubChem (6432564)
PubChem (6710666)
PubChem (124146240)
PubChem (56621683)
PubChem (7059399)
PubChem (124897607)
PubChem (124896959)
PubChem (10861996)
PubChem (132837164)
PubChem (11834483)
PubChem (11888915)
PubChem (11888914)
PubChem (57915018)
PubChem (57939063)
PubChem (138967089)
PubChem (58428240)
PubChem (58445498)
PubChem (139566851)
PubChem (58663286)
PubChem (15939944)
PubChem (59450329)
PubChem (59628412)
PubChem (171828367)
PubChem (173516975)
PubChem (59965215)
PubChem (71234641)
PubChem (59993755)
PubChem (60001463)
PubChem (66634651)
PubChem (68055877)
PubChem (68166463)
PubChem (68315613)
PubChem (70795838)
PubChem (70797612)
PubChem (70954610)
PubChem (70957185)
PubChem (71463909)
PubChem (89951918)
PubChem (90224410)
PubChem (91298236)
PubChem (101624109)
PubChem (124225449)
PubChem (124429284)
PubChem (124909223)
PubChem (124909224)
PubChem (124909225)
PubChem (130459183)
PubChem (131992107)
PubChem (139568882)
PubChem (142983773)
PubChem (144054483)
PubChem (144209461)
PubChem (144331236)
PubChem (144808354)
PubChem (145053568)
PubChem (145157652)
PubChem (145215073)
PubChem (145230478)
PubChem (146320991)
PubChem (147857230)
PubChem (154993519)
PubChem (158603858)
PubChem (162906452)
PubChem (162906453)
PubChem (162906454)
PubChem (162906455)
PubChem (162906456)
PubChem (162906457)
PubChem (163255768)
PubChem (163389210)
PubChem (164665303)
PubChem (166553771)
PubChem (166712004)
PubChem (170116175)
PubChem (171764280)
PubChem (171817101)
PubChem (171817104)
PubChem (174285573)
7H
(R)		4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-N,N-dimethyl-2,2-diphenylbutanamidenon-polymer477.01Chemie (A1CMV)
PubChem (3955)
Sequence modifications
B: 2 - 340 (UniProt: P62873)
PDBExternal DatabaseDetails
His -20-expression tag
His -19-expression tag
His -18-expression tag
His -17-expression tag
His -16-expression tag
His -15-expression tag
His -14-expression tag
His -13-expression tag
His -12-expression tag
His -11-expression tag
Leu -10-expression tag
Glu -9-expression tag
Val -8-expression tag
Leu -7-expression tag
Phe -6-expression tag
Gln -5-expression tag
Gly -4-expression tag
Pro -3-expression tag
Gly -2-expression tag
Ser -1-expression tag
Ser 0-expression tag
Gly 1-expression tag
R: -108 - -3 (UniProt: P0ABE7)
PDBExternal DatabaseDetails
Met -169-initiating methionine
Lys -168-expression tag
Thr -167-expression tag
Ile -166-expression tag
Ile -165-expression tag
Ala -164-expression tag
Leu -163-expression tag
Ser -162-expression tag
Tyr -161-expression tag
Ile -160-expression tag
Phe -159-expression tag
Cys -158-expression tag
Leu -157-expression tag
Val -156-expression tag
Phe -155-expression tag
Ala -154-expression tag
Asp -153-expression tag
Tyr -152-expression tag
Lys -151-expression tag
Asp -150-expression tag
His -149-expression tag
Asp -148-expression tag
Gly -147-expression tag
Asp -146-expression tag
Tyr -145-expression tag
Lys -144-expression tag
Asp -143-expression tag
His -142-expression tag
Asp -141-expression tag
Ile -140-expression tag
Asp -139-expression tag
Tyr -138-expression tag
Lys -137-expression tag
Asp -136-expression tag
Asp -135-expression tag
Asp -134-expression tag
Asp -133-expression tag
Lys -132-expression tag
Leu -131-expression tag
His -130-expression tag
His -129-expression tag
His -128-expression tag
His -127-expression tag
His -126-expression tag
His -125-expression tag
His -124-expression tag
His -123-expression tag
His -122-expression tag
His -121-expression tag
Leu -120-expression tag
Glu -119-expression tag
Val -118-expression tag
Leu -117-expression tag
Phe -116-expression tag
Gln -115-expression tag
Gly -114-expression tag
Pro -113-expression tag
Gly -112-expression tag
Ser -111-expression tag
Gly -110-expression tag
Ser -109-expression tag
Trp -102Met 29conflict
Ile -7His 124conflict
Leu -3Arg 128conflict
Gly -2-linker
Thr -1-linker
Gly 0-linker
Ser 1-linker
R: 2 - 400 (UniProt: P35372)
PDBExternal DatabaseDetails
Ala 401-expression tag
Ala 402-expression tag
Ala 403-expression tag
Leu 404-expression tag
Glu 405-expression tag
Val 406-expression tag
Leu 407-expression tag
Phe 408-expression tag
Gln 409-expression tag
Gly 410-expression tag
Pro 411-expression tag
Gly 412-expression tag
Ser 413-expression tag
Trp 414-expression tag
Ser 415-expression tag
His 416-expression tag
Pro 417-expression tag
Gln 418-expression tag
Phe 419-expression tag
Glu 420-expression tag
Lys 421-expression tag
Gly 422-expression tag
Gly 423-expression tag
Gly 424-expression tag
Ser 425-expression tag
Gly 426-expression tag
Gly 427-expression tag
Gly 428-expression tag
Ser 429-expression tag
Gly 430-expression tag
Gly 431-expression tag
Ser 432-expression tag
Ser 433-expression tag
Ala 434-expression tag
Trp 435-expression tag
Ser 436-expression tag
His 437-expression tag
Pro 438-expression tag
Gln 439-expression tag
Phe 440-expression tag
Glu 441-expression tag
Lys 442-expression tag
His 443-expression tag
His 444-expression tag
His 445-expression tag
His 446-expression tag
His 447-expression tag
His 448-expression tag
His 449-expression tag
His 450-expression tag
His 451-expression tag
His 452-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains4
Total formula weight157656.0
Non-Polymers*Number of molecules4
Total formula weight1709.6
All*Total formula weight159365.6
*Water molecules are not included.

251801

PDB entries from 2026-04-08

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