9PXY
Primed-state naloxone-mu opioid receptor-Gi GDPbS complex (rebound)
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (R) | Soluble cytochrome b562,Mu-type opioid receptor,Soluble cytochrome b562,Mu-type opioid receptor,Mu opioid receptor | polymer | 622 | 69540.4 | 1 | UniProt (P0ABE7) UniProt (P35372) Pfam (PF00001) | Homo sapiens (human) | Cytochrome b-562,M-OR-1,MOR-1,Mu opiate receptor,Mu opioid receptor,MOP,hMOP |
| 2 | B (A) | Guanine nucleotide-binding protein G(i) subunit alpha-1 | polymer | 354 | 40415.0 | 1 | UniProt (P63096) Pfam (PF00503) | Homo sapiens (human) | Adenylate cyclase-inhibiting G alpha protein |
| 3 | C (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 361 | 39839.5 | 1 | UniProt (P62873) Pfam (PF25391) | Homo sapiens (human) | Transducin beta chain 1 |
| 4 | D (C) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (human) | G gamma-I |
| 5 | E, F (R) | CHOLESTEROL | non-polymer | 386.7 | 2 | Chemie (CLR) PubChem (304) PubChem (191463) PubChem (368063) PubChem (369319) PubChem (638019) PubChem (1549081) PubChem (1553803) PubChem (5283629) PubChem (5284644) PubChem (5315842) PubChem (6419195) PubChem (6994560) PubChem (7055705) PubChem (7055706) PubChem (7059398) PubChem (7059400) PubChem (7059635) PubChem (7103033) PubChem (7182477) PubChem (7182478) PubChem (9909206) PubChem (10045721) PubChem (71168115) PubChem (10134774) PubChem (10293553) PubChem (71173031) PubChem (11003580) PubChem (11025495) PubChem (11058155) PubChem (11463329) PubChem (11868624) PubChem (11868625) PubChem (11869366) PubChem (11869367) PubChem (11869368) PubChem (11869369) PubChem (12120344) PubChem (12156156) PubChem (12303135) PubChem (12303148) PubChem (12303156) PubChem (12303159) PubChem (12303160) PubChem (16219173) PubChem (16758052) PubChem (40477506) PubChem (40557614) PubChem (42579431) PubChem (42579432) PubChem (176980071) PubChem (45044259) PubChem (18640088) PubChem (1715243) PubChem (1715244) PubChem (23423981) PubChem (49853509) PubChem (44654663) PubChem (46937002) PubChem (59274407) PubChem (50990013) PubChem (68311425) PubChem (68311398) PubChem (143173313) PubChem (177156123) PubChem (5997) PubChem (1551269) PubChem (90070115) PubChem (52934537) PubChem (117965027) PubChem (6432564) PubChem (6710666) PubChem (124146240) PubChem (56621683) PubChem (7059399) PubChem (124897607) PubChem (124896959) PubChem (10861996) PubChem (132837164) PubChem (11834483) PubChem (11888915) PubChem (11888914) PubChem (57915018) PubChem (57939063) PubChem (138967089) PubChem (58428240) PubChem (58445498) PubChem (139566851) PubChem (58663286) PubChem (15939944) PubChem (59450329) PubChem (59628412) PubChem (171828367) PubChem (173516975) PubChem (59965215) PubChem (71234641) PubChem (59993755) PubChem (60001463) PubChem (66634651) PubChem (68055877) PubChem (68166463) PubChem (68315613) PubChem (70795838) PubChem (70797612) PubChem (70954610) PubChem (70957185) PubChem (71463909) PubChem (89951918) PubChem (90224410) PubChem (91298236) PubChem (101624109) PubChem (124225449) PubChem (124429284) PubChem (124909223) PubChem (124909224) PubChem (124909225) PubChem (130459183) PubChem (131992107) PubChem (139568882) PubChem (142983773) PubChem (144054483) PubChem (144209461) PubChem (144331236) PubChem (144808354) PubChem (145053568) PubChem (145157652) PubChem (145215073) PubChem (145230478) PubChem (146320991) PubChem (147857230) PubChem (154993519) PubChem (158603858) PubChem (162906452) PubChem (162906453) PubChem (162906454) PubChem (162906455) PubChem (162906456) PubChem (162906457) PubChem (163255768) PubChem (163389210) PubChem (164665303) PubChem (166553771) PubChem (166712004) PubChem (170116175) PubChem (171764280) PubChem (171817101) PubChem (171817104) PubChem (174285573) | |||
| 6 | G (R) | Naloxone | non-polymer | 327.4 | 1 | Chemie (A1APV) PubChem (4425) PubChem (10064) PubChem (5284596) PubChem (5390107) PubChem (5491858) PubChem (5702090) PubChem (6321250) PubChem (6545909) PubChem (6918998) PubChem (11957637) PubChem (13303869) PubChem (13303870) PubChem (13303871) PubChem (13303872) PubChem (13303874) PubChem (13303875) PubChem (13303879) PubChem (13303883) PubChem (13303884) PubChem (16395294) PubChem (16682422) PubChem (18530270) PubChem (23786505) PubChem (42606788) PubChem (186822) PubChem (667494) PubChem (51691054) PubChem (9818787) PubChem (13303876) PubChem (58647324) PubChem (66624200) PubChem (68336375) PubChem (71774987) PubChem (89727402) PubChem (98185014) PubChem (117753977) PubChem (126538501) PubChem (129035763) PubChem (155086808) PubChem (161235492) PubChem (167122378) | |||
| 7 | H (A) | 5'-O-[(R)-hydroxy(thiophosphonooxy)phosphoryl]guanosine | non-polymer | 459.3 | 1 | Chemie (VSN) PubChem (135583303) PubChem (137258001) PubChem (135410865) PubChem (135457564) PubChem (135487899) PubChem (135707695) PubChem (136663988) PubChem (137218939) PubChem (155817661) PubChem (162290140) PubChem (163901066) |
Sequence modifications
R: -108 - -4 (UniProt: P0ABE7)
R: 2 - 400 (UniProt: P35372)
R: 401 - 452 (PDB: 9PXY)
B: 2 - 340 (UniProt: P62873)
| PDB | External Database | Details |
|---|---|---|
| Met -169 | - | expression tag |
| Lys -168 | - | expression tag |
| Thr -167 | - | expression tag |
| Ile -166 | - | expression tag |
| Ile -165 | - | expression tag |
| Ala -164 | - | expression tag |
| Leu -163 | - | expression tag |
| Ser -162 | - | expression tag |
| Tyr -161 | - | expression tag |
| Ile -160 | - | expression tag |
| Phe -159 | - | expression tag |
| Cys -158 | - | expression tag |
| Leu -157 | - | expression tag |
| Val -156 | - | expression tag |
| Phe -155 | - | expression tag |
| Ala -154 | - | expression tag |
| Asp -153 | - | expression tag |
| Tyr -152 | - | expression tag |
| Lys -151 | - | expression tag |
| Asp -150 | - | expression tag |
| His -149 | - | expression tag |
| Asp -148 | - | expression tag |
| Gly -147 | - | expression tag |
| Asp -146 | - | expression tag |
| Tyr -145 | - | expression tag |
| Lys -144 | - | expression tag |
| Asp -143 | - | expression tag |
| His -142 | - | expression tag |
| Asp -141 | - | expression tag |
| Ile -140 | - | expression tag |
| Asp -139 | - | expression tag |
| Tyr -138 | - | expression tag |
| Lys -137 | - | expression tag |
| Asp -136 | - | expression tag |
| Asp -135 | - | expression tag |
| Asp -134 | - | expression tag |
| Asp -133 | - | expression tag |
| Lys -132 | - | expression tag |
| Leu -131 | - | expression tag |
| His -130 | - | expression tag |
| His -129 | - | expression tag |
| His -128 | - | expression tag |
| His -127 | - | expression tag |
| His -126 | - | expression tag |
| His -125 | - | expression tag |
| His -124 | - | expression tag |
| His -123 | - | expression tag |
| His -122 | - | expression tag |
| His -121 | - | expression tag |
| Leu -120 | - | expression tag |
| Glu -119 | - | expression tag |
| Val -118 | - | expression tag |
| Leu -117 | - | expression tag |
| Phe -116 | - | expression tag |
| Gln -115 | - | expression tag |
| Gly -114 | - | expression tag |
| Pro -113 | - | expression tag |
| Gly -112 | - | expression tag |
| Ser -111 | - | expression tag |
| Gly -110 | - | expression tag |
| Ser -109 | - | expression tag |
| Trp -102 | Met 29 | conflict |
| Ile -7 | His 124 | conflict |
| Leu -3 | - | linker |
| Gly -2 | - | linker |
| Thr -1 | - | linker |
| Gly 0 | - | linker |
| Ser 1 | - | linker |
R: 401 - 452 (PDB: 9PXY)
B: 2 - 340 (UniProt: P62873)
| PDB | External Database | Details |
|---|---|---|
| His -20 | - | expression tag |
| His -19 | - | expression tag |
| His -18 | - | expression tag |
| His -17 | - | expression tag |
| His -16 | - | expression tag |
| His -15 | - | expression tag |
| His -14 | - | expression tag |
| His -13 | - | expression tag |
| His -12 | - | expression tag |
| His -11 | - | expression tag |
| Leu -10 | - | expression tag |
| Glu -9 | - | expression tag |
| Val -8 | - | expression tag |
| Leu -7 | - | expression tag |
| Phe -6 | - | expression tag |
| Gln -5 | - | expression tag |
| Gly -4 | - | expression tag |
| Pro -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Gly 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 157656.0 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1559.9 | |
| All* | Total formula weight | 159216.0 |
