9PX5

Crystal structure of Fab 7268 in complex with MBP-TREM2 Ig domain fusion

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Maltose/maltodextrin-binding periplasmic protein,Triggering receptor expressed on myeloid cells 2	polymer	492	54172.1	1	UniProt (P0AEX9) UniProt (Q9NZC2) Pfam (PF01547) Pfam (PF07686)	Escherichia coli
2	B (H)	7268 Fab Heavy Chain	polymer	226	24081.0	1		Homo sapiens
3	C (L)	7268 Fab Light Chain	polymer	214	23363.9	1		Homo sapiens
4	D (B)	alpha-D-glucopyranose-(1-4)-beta-D-glucopyranose	branched		342.3	1	In PDB GlyTouCan (G66120GK)
5	E, F (A)	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)

Sequence modifications

A: -349 - 16 (UniProt: P0AEX9)

PDB	External Database	Details
Thr -348	Ile 28	conflict
Ala -268	Asp 108	conflict
Ala -267	Lys 109	conflict
Ala -178	Glu 198	conflict
Ala -177	Asn 199	conflict
His -135	Ala 241	conflict
His -131	Lys 245	conflict
Ala -111	Lys 265	conflict
Val -38	Ala 338	conflict
Val -33	Ile 343	conflict
Ala 9	Glu 385	conflict
Ala 12	Lys 388	conflict
Ala 13	Asp 389	conflict
Asn 17	-	linker

A: 18 - 135 (UniProt: Q9NZC2)

PDB	External Database	Details
Asp 20	Asn 20	conflict
His 136	-	expression tag
His 137	-	expression tag
His 138	-	expression tag
His 139	-	expression tag
His 140	-	expression tag
His 141	-	expression tag
His 142	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	101617.0
Branched	Number of molecules	1
	Total formula weight	342.3
Non-Polymers*	Number of molecules	2
	Total formula weight	192.1
All*	Total formula weight	102151.4

*Water molecules are not included.