9PWG
The pre-open state (pre-OM, 20C), menthol-bound mouse TRPM8-I846V in complex with AITC and PIP2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Transient receptor potential cation channel subfamily M member 8 | polymer | 1104 | 127841.5 | 4 | UniProt (Q8R4D5) Pfam (PF18139) Pfam (PF25508) Pfam (PF00520) | Mus musculus (house mouse) | Long transient receptor potential channel 6,LTrpC-6,LTrpC6,Transient receptor potential p8,Trp-p8 |
| 2 | E, I, L, O (A, B, C, D) | [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate | non-polymer | 746.6 | 4 | Chemie (PIO) | |||
| 3 | F, J, M, P (A, B, C, D) | (1R,2S,5R)-5-methyl-2-(propan-2-yl)cyclohexan-1-ol | non-polymer | 156.3 | 4 | Chemie (XUQ) PubChem (16666) | |||
| 4 | G, H, K, N (A, B, C, D) | 3-isothiocyanatoprop-1-ene | non-polymer | 99.2 | 4 | Chemie (UL9) PubChem (5971) |
Sequence modifications
A, B, C, D: 1 - 1104 (UniProt: Q8R4D5)
| PDB | External Database | Details |
|---|---|---|
| Val 846 | Ile 846 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 511365.9 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 4007.9 | |
| All* | Total formula weight | 515373.8 |
