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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9PT4

Cryo-EM structure of GPR84-Gi complex bound to OX04529

This is a non-PDB format compatible entry.
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(R)		G-protein coupled receptor 84polymer61567569.21UniProt (Q9NQS5)
Pfam (PF00001)		Homo sapiens (human)Inflammation-related G-protein coupled receptor EX33
2B
(A)		Guanine nucleotide-binding protein G(i) subunit alpha-1polymer35440414.01UniProt (P63096)
Pfam (PF00503)		Homo sapiens (human)Adenylate cyclase-inhibiting G alpha protein
3C
(B)		Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1polymer37640845.61UniProt (P62873)
Pfam (PF25391)		Homo sapiens (human)
4D
(G)		Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2polymer717861.11UniProt (P59768)
Pfam (PF00631)		Homo sapiens (human)G gamma-I
5E
(N)		scFv16polymer26628634.81Mus musculus (Mouse)
6F
(R)		5-[3-[4-chloranyl-3-(trifluoromethyl)phenyl]propyl]-1-oxidanyl-pyridin-3-olnon-polymer331.71Chemie (A1CKT)
7G
(R)		CHOLESTEROLnon-polymer386.71Chemie (CLR)
PubChem (5997)
Sequence modifications
R: 1 - 387 (UniProt: Q9NQS5)
PDBExternal DatabaseDetails
Asp -52-expression tag
Tyr -51-expression tag
Lys -50-expression tag
Asp -49-expression tag
Asp -48-expression tag
Asp -47-expression tag
Asp -46-expression tag
His -45-expression tag
His -44-expression tag
His -43-expression tag
His -42-expression tag
His -41-expression tag
His -40-expression tag
His -39-expression tag
His -38-expression tag
Gly -37-expression tag
Gln -36-expression tag
Pro -35-expression tag
Gly -34-expression tag
Asn -33-expression tag
Gly -32-expression tag
Ser -31-expression tag
Ala -30-expression tag
Phe -29-expression tag
Leu -28-expression tag
Leu -27-expression tag
Ala -26-expression tag
Pro -25-expression tag
Asn -24-expression tag
Gly -23-expression tag
Ser -22-expression tag
His -21-expression tag
Ala -20-expression tag
Pro -19-expression tag
Asp -18-expression tag
His -17-expression tag
Asn -16-expression tag
Val -15-expression tag
Thr -14-expression tag
Gln -13-expression tag
Gln -12-expression tag
Arg -11-expression tag
Asp -10-expression tag
Glu -9-expression tag
Glu -8-expression tag
Asn -7-expression tag
Leu -6-expression tag
Tyr -5-expression tag
Phe -4-expression tag
Gln -3-expression tag
Gly -2-expression tag
Val -1-expression tag
Asp 0-expression tag
His 388-expression tag
Met 389-expression tag
Gly 390-expression tag
Ser 391-expression tag
Ser 392-expression tag
Gly 393-expression tag
Gly 394-expression tag
Gly 395-expression tag
Gly 396-expression tag
Ser 397-expression tag
Gly 398-expression tag
Gly 399-expression tag
Gly 400-expression tag
Gly 401-expression tag
Ser 402-expression tag
Ser 403-expression tag
Gly 404-expression tag
Val 405-expression tag
Phe 406-expression tag
Thr 407-expression tag
Leu 408-expression tag
Glu 409-expression tag
Asp 410-expression tag
Phe 411-expression tag
Val 412-expression tag
Gly 413-expression tag
Asp 414-expression tag
Trp 415-expression tag
Glu 416-expression tag
Gln 417-expression tag
Thr 418-expression tag
Ala 419-expression tag
Ala 420-expression tag
Tyr 421-expression tag
Asn 422-expression tag
Leu 423-expression tag
Asp 424-expression tag
Gln 425-expression tag
Val 426-expression tag
Leu 427-expression tag
Glu 428-expression tag
Gln 429-expression tag
Gly 430-expression tag
Gly 431-expression tag
Val 432-expression tag
Ser 433-expression tag
Ser 434-expression tag
Leu 435-expression tag
Leu 436-expression tag
Gln 437-expression tag
Asn 438-expression tag
Leu 439-expression tag
Ala 440-expression tag
Val 441-expression tag
Ser 442-expression tag
Val 443-expression tag
Thr 444-expression tag
Pro 445-expression tag
Ile 446-expression tag
Gln 447-expression tag
Arg 448-expression tag
Ile 449-expression tag
Val 450-expression tag
Arg 451-expression tag
Ser 452-expression tag
Gly 453-expression tag
Glu 454-expression tag
Asn 455-expression tag
Ala 456-expression tag
Leu 457-expression tag
Lys 458-expression tag
Ile 459-expression tag
Asp 460-expression tag
Ile 461-expression tag
His 462-expression tag
Val 463-expression tag
Ile 464-expression tag
Ile 465-expression tag
Pro 466-expression tag
Tyr 467-expression tag
Glu 468-expression tag
Gly 469-expression tag
Leu 470-expression tag
Ser 471-expression tag
Ala 472-expression tag
Asp 473-expression tag
Gln 474-expression tag
Met 475-expression tag
Ala 476-expression tag
Gln 477-expression tag
Ile 478-expression tag
Glu 479-expression tag
Glu 480-expression tag
Val 481-expression tag
Phe 482-expression tag
Lys 483-expression tag
Val 484-expression tag
Val 485-expression tag
Tyr 486-expression tag
Pro 487-expression tag
Val 488-expression tag
Asp 489-expression tag
Asp 490-expression tag
His 491-expression tag
His 492-expression tag
Phe 493-expression tag
Lys 494-expression tag
Val 495-expression tag
Ile 496-expression tag
Leu 497-expression tag
Pro 498-expression tag
Tyr 499-expression tag
Gly 500-expression tag
Thr 501-expression tag
Leu 502-expression tag
Val 503-expression tag
Ile 504-expression tag
Asp 505-expression tag
Gly 506-expression tag
Val 507-expression tag
Thr 508-expression tag
Pro 509-expression tag
Asn 510-expression tag
Met 511-expression tag
Leu 512-expression tag
Asn 513-expression tag
Tyr 514-expression tag
Phe 515-expression tag
Gly 516-expression tag
Arg 517-expression tag
Pro 518-expression tag
Tyr 519-expression tag
Glu 520-expression tag
Gly 521-expression tag
Ile 522-expression tag
Ala 523-expression tag
Val 524-expression tag
Phe 525-expression tag
Asp 526-expression tag
Gly 527-expression tag
Lys 528-expression tag
Lys 529-expression tag
Ile 530-expression tag
Thr 531-expression tag
Val 532-expression tag
Thr 533-expression tag
Gly 534-expression tag
Thr 535-expression tag
Leu 536-expression tag
Trp 537-expression tag
Asn 538-expression tag
Gly 539-expression tag
Asn 540-expression tag
Lys 541-expression tag
Ile 542-expression tag
Ile 543-expression tag
Asp 544-expression tag
Glu 545-expression tag
Arg 546-expression tag
Leu 547-expression tag
Ile 548-expression tag
Thr 549-expression tag
Pro 550-expression tag
Asp 551-expression tag
Gly 552-expression tag
Ser 553-expression tag
Met 554-expression tag
Leu 555-expression tag
Phe 556-expression tag
Arg 557-expression tag
Val 558-expression tag
Thr 559-expression tag
Ile 560-expression tag
Asn 561-expression tag
Ser 562-expression tag
A: 1 - 354 (UniProt: P63096)
PDBExternal DatabaseDetails
Asn 47Ser 47engineered mutation
Ala 203Gly 203engineered mutation
Ala 245Glu 245engineered mutation
Ser 326Ala 326engineered mutation
B: 2 - 340 (UniProt: P62873)
PDBExternal DatabaseDetails
Met -9-initiating methionine
His -8-expression tag
His -7-expression tag
His -6-expression tag
His -5-expression tag
His -4-expression tag
His -3-expression tag
Gly -2-expression tag
Ser -1-expression tag
Ser 0-expression tag
Gly 1-expression tag
Gly 341-expression tag
Ser 342-expression tag
Ser 343-expression tag
Gly 344-expression tag
Gly 345-expression tag
Gly 346-expression tag
Gly 347-expression tag
Ser 348-expression tag
Gly 349-expression tag
Gly 350-expression tag
Gly 351-expression tag
Gly 352-expression tag
Ser 353-expression tag
Ser 354-expression tag
Gly 355-expression tag
Val 356-expression tag
Ser 357-expression tag
Gly 358-expression tag
Trp 359-expression tag
Arg 360-expression tag
Leu 361-expression tag
Phe 362-expression tag
Lys 363-expression tag
Lys 364-expression tag
Ile 365-expression tag
Ser 366-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains5
Total formula weight185324.7
Non-Polymers*Number of molecules2
Total formula weight718.4
All*Total formula weight186043.1
*Water molecules are not included.

257179

PDB entries from 2026-07-29

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