9PST

IRAK4 in Complex with Compound 5

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Interleukin-1 receptor-associated kinase 4	polymer	304	34215.5	4	UniProt (Q9NWZ3) Pfam (PF07714)	Homo sapiens (human)	IRAK-4,Renal carcinoma antigen NY-REN-64
2	E, F, I, J (A, B, C, D)	N-[(1R,4r)-4-(5-{(6P)-6-[(8R)-3-cyanopyrrolo[1,2-b]pyridazin-7-yl]-4-[(propan-2-yl)amino]pyridin-3-yl}-1,3,4-thiadiazol-2-yl)cyclohexyl]acetamide	non-polymer		500.6	4	Chemie (A1CKQ)
3	G, H, K, L (B, D)	SULFATE ION	non-polymer		96.1	4	Chemie (SO4)
4	M, N, O, P (A, B, C, D)	water	water		18.0	519	Chemie (HOH)

Sequence modifications

A, B, C, D: 160 - 460 (UniProt: Q9NWZ3)

PDB	External Database	Details
Gly 157	-	expression tag
Ala 158	-	expression tag
Met 159	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	136862.1
Non-Polymers*	Number of molecules	8
	Total formula weight	2386.7
All*	Total formula weight	139248.8

*Water molecules are not included.