9PN0

Structure of HTTQ23-HAP40 complex bound to macrocycles HHD3, HD4 and HL2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (D)	HD4	polymer	19	2024.4	1		synthetic construct
2	B (C)	HHD3	polymer	19	2423.7	1		synthetic construct
3	C (E)	HL2	polymer	17	1830.2	1		synthetic construct
4	D (A)	Huntingtin	polymer	3156	349472.3	1	UniProt (P42858) Pfam (PF20926) Pfam (PF20925) Pfam (PF20927)	Homo sapiens (human)	Huntington disease protein,HD protein
5	E (B)	40-kDa huntingtin-associated protein	polymer	389	41342.3	1	UniProt (P23610)	Homo sapiens (human)	HAP40,CpG island protein,Factor VIII intron 22 protein

Sequence modifications

A: 1 - 3144 (UniProt: P42858)

PDB	External Database	Details
Gln 39	-	insertion
Gln 40	-	insertion
His 2311	Tyr 2309	conflict
Ile 2788	Val 2786	conflict
Gly 3145	-	expression tag
Gly 3146	-	expression tag
Ser 3147	-	expression tag
Gly 3148	-	expression tag
Asp 3149	-	expression tag
Tyr 3150	-	expression tag
Lys 3151	-	expression tag
Asp 3152	-	expression tag
Asp 3153	-	expression tag
Asp 3154	-	expression tag
Asp 3155	-	expression tag
Lys 3156	-	expression tag

B: 1 - 371 (UniProt: P23610)

PDB	External Database	Details
Met -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
Ser -10	-	expression tag
Ser -9	-	expression tag
Gly -8	-	expression tag
Arg -7	-	expression tag
Glu -6	-	expression tag
Asn -5	-	expression tag
Leu -4	-	expression tag
Tyr -3	-	expression tag
Phe -2	-	expression tag
Gln -1	-	expression tag
Gly 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	397092.8
All*	Total formula weight	397092.8

*Water molecules are not included.