9PLL

TRIM21-NUP98 Molecular Glue Complex (MAN-056)

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (B)	E3 ubiquitin-protein ligase TRIM21	polymer	184	20736.2	1	UniProt (P19474) Pfam (PF13765) Pfam (PF00622)	Homo sapiens (human)	52 kDa Ro protein,52 kDa ribonucleoprotein autoantigen Ro/SS-A,RING finger protein 81,Ro(SS-A),Sjoegren syndrome type A antigen,SS-A,Tripartite motif-containing protein 21
2	B (C)	Isoform 2 of Nuclear pore complex protein Nup98-Nup96	polymer	171	19535.0	1	UniProt (P52948) Pfam (PF04096)	Homo sapiens (human)
3	C (B)	(3P)-3-(4-chloro-2-ethoxyphenyl)-6-fluoro-2-[(piperazin-1-yl)methyl]quinazolin-4(3H)-one	non-polymer		416.9	1	Chemie (A1BLD) PubChem (176508677)
4	D (B)	GLYCEROL	non-polymer		92.1	1	Chemie (GOL) PubChem (753)
5	E, F (B, C)	water	water		18.0	320	Chemie (HOH)

Sequence modifications

B: 284 - 465 (UniProt: P19474)

PDB	External Database	Details
Ser 282	-	expression tag
Gly 283	-	expression tag
Ser 285	Cys 285	engineered mutation

C: 712 - 863 (UniProt: P52948)

PDB	External Database	Details
Met 693	-	initiating methionine
Lys 694	-	expression tag
Ser 695	-	expression tag
Ser 696	-	expression tag
His 697	-	expression tag
His 698	-	expression tag
His 699	-	expression tag
His 700	-	expression tag
His 701	-	expression tag
His 702	-	expression tag
Glu 703	-	expression tag
Asn 704	-	expression tag
Leu 705	-	expression tag
Tyr 706	-	expression tag
Phe 707	-	expression tag
Gln 708	-	expression tag
Ser 709	-	expression tag
Asn 710	-	expression tag
Ala 711	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	40271.3
Non-Polymers*	Number of molecules	2
	Total formula weight	509.0
All*	Total formula weight	40780.3

*Water molecules are not included.