9PFM
Crystal structure of human 15-PGDH in complex with small molecule compound 8b
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | polymer | 259 | 28159.2 | 1 | UniProt (P15428) Pfam (PF00106) | Homo sapiens (human) | 15-PGDH,Eicosanoid/docosanoid dehydrogenase [NAD(+)],Prostaglandin dehydrogenase 1,Short chain dehydrogenase/reductase family 36C member 1 |
| 2 | B (A) | NICOTINAMIDE-ADENINE-DINUCLEOTIDE | non-polymer | 663.4 | 1 | Chemie (NAD) | |||
| 3 | C (A) | 2-[butyl(oxidanyl)-$l^{3}-sulfanyl]-4-(2,3-dimethylimidazol-4-yl)-6-(1,3-thiazol-2-yl)thieno[2,3-b]pyridin-3-amine | non-polymer | 433.6 | 1 | Chemie (SWL) | |||
| 4 | D, E (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
| 5 | F (A) | water | water | 18.0 | 95 | Chemie (HOH) |
Sequence modifications
A: 2 - 259 (UniProt: P15428)
| PDB | External Database | Details |
|---|---|---|
| Ser 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 28159.2 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1221.2 | |
| All* | Total formula weight | 29380.4 |
