9PE8

CDK6 to CDK4 active site surrogate in complex with PF-07220060

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Cyclin-dependent kinase 6	polymer	307	35018.2	1	UniProt (Q00534) Pfam (PF00069)	Homo sapiens (human)	Cell division protein kinase 6,Serine/threonine-protein kinase PLSTIRE
2	B (A)	Atirmociclib	non-polymer		463.9	1	Chemie (A1AZ4)
3	C (A)	water	water		18.0	177	Chemie (HOH)

Sequence modifications

A: 1 - 301 (UniProt: Q00534)

PDB	External Database	Details
Val 21	Glu 21	engineered mutation
Thr 26	Lys 26	engineered mutation
Arg 106	Thr 106	engineered mutation
Glu 149	Gln 149	engineered mutation
His 302	-	expression tag
His 303	-	expression tag
His 304	-	expression tag
His 305	-	expression tag
His 306	-	expression tag
His 307	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	35018.2
Non-Polymers*	Number of molecules	1
	Total formula weight	463.9
All*	Total formula weight	35482.2

*Water molecules are not included.