9PE7
CDK6 to CDK4 active site surrogate in complex with compound 6
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Cyclin-dependent kinase 6 | polymer | 307 | 35018.2 | 1 | UniProt (Q00534) Pfam (PF00069) | Homo sapiens (human) | Cell division protein kinase 6,Serine/threonine-protein kinase PLSTIRE |
| 2 | B (A) | (3R,4R)-4-({(4M)-5-fluoro-4-[4-fluoro-2-methyl-1-(propan-2-yl)-1H-1,3-benzimidazol-6-yl]pyrimidin-2-yl}amino)-1-(methanesulfonyl)piperidin-3-ol | non-polymer | 480.5 | 1 | Chemie (A1CIF) | |||
| 3 | C (A) | water | water | 18.0 | 125 | Chemie (HOH) |
Sequence modifications
A: 1 - 301 (UniProt: Q00534)
| PDB | External Database | Details |
|---|---|---|
| Val 21 | Glu 21 | engineered mutation |
| Thr 26 | Lys 26 | engineered mutation |
| Arg 106 | Thr 106 | engineered mutation |
| Glu 149 | Gln 149 | engineered mutation |
| His 302 | - | expression tag |
| His 303 | - | expression tag |
| His 304 | - | expression tag |
| His 305 | - | expression tag |
| His 306 | - | expression tag |
| His 307 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 35018.2 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 480.5 | |
| All* | Total formula weight | 35498.8 |
