9P9G

Active substate 5 of the GluA4 homotetramer.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Isoform 2 of Glutamate receptor 4	polymer	846	95140.2	4	UniProt (P19493)	Rattus norvegicus (Norway rat)	GluR-4,GluR4,AMPA-selective glutamate receptor 4,GluR-D,Glutamate receptor ionotropic,AMPA 4,GluA4
2	E, F, G, H (H, F, G, E)	Voltage-dependent calcium channel gamma-2 subunit	polymer	209	23066.5	4	UniProt (O88602)	Mus musculus (house mouse)	Neuronal voltage-gated calcium channel gamma-2 subunit,Stargazin,Transmembrane AMPAR regulatory protein gamma-2,TARP gamma-2
3	I, L, O, P (A, B, C, D)	GLUTAMIC ACID	non-polymer		147.1	4	Chemie (GLU)
4	J, K, M, N (A, B)	CYCLOTHIAZIDE	non-polymer		389.9	4	Chemie (CYZ)

Sequence modifications

A, B, C, D: 25 - 848 (UniProt: P19493)

PDB	External Database	Details
Met 3	-	initiating methionine
Gly 4	-	expression tag
Lys 5	-	expression tag
Ile 6	-	expression tag
Met 7	-	expression tag
His 8	-	expression tag
Ile 9	-	expression tag
Ser 10	-	expression tag
Val 11	-	expression tag
Leu 12	-	expression tag
Leu 13	-	expression tag
Ser 14	-	expression tag
Pro 15	-	expression tag
Val 16	-	expression tag
Leu 17	-	expression tag
Trp 18	-	expression tag
Gly 19	-	expression tag
Leu 20	-	expression tag
Ile 21	-	expression tag
Phe 22	-	expression tag
Gly 23	-	expression tag
Val 24	-	expression tag
Ile 734	Thr 734	conflict

H, F, G, E: 2 - 208 (UniProt: O88602)

PDB	External Database	Details
Asp 48	Asn 48	conflict
Thr 209	-	expression tag
Gly 210	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	472826.9
Non-Polymers*	Number of molecules	8
	Total formula weight	2148.0
All*	Total formula weight	474975.0

*Water molecules are not included.