9P97
CryoEM structure of the closed integrin alphaEbeta7 bound to fab LF61
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Integrin alpha-E | polymer | 1176 | 129950.2 | 1 | UniProt (P38570) Pfam (PF00092) Pfam (PF01839) Pfam (PF20805) | Homo sapiens (human) | HML-1 antigen,Integrin alpha-IEL,Mucosal lymphocyte 1 antigen |
| 2 | B (B) | Integrin beta-7 | polymer | 776 | 84538.8 | 1 | UniProt (P26010) Pfam (PF17205) Pfam (PF00362) Pfam (PF07974) | Homo sapiens (human) | Gut homing receptor beta subunit |
| 3 | C (H) | Fab LF61 Heavy Chain | polymer | 220 | 23634.6 | 1 | Mus musculus | ||
| 4 | D (L) | Fab LF61 Light Chain | polymer | 215 | 23439.4 | 1 | Mus musculus | ||
| 5 | E (C) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 1 | In PDB GlyTouCan (G22768VO) | |||
| 6 | F, H (D, F) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
| 7 | G (E) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G15407YE) | |||
| 8 | I, J, P (A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 3 | Chemie (NAG) | |||
| 9 | K, L, M, N, O... (A, B) | CALCIUM ION | non-polymer | 40.1 | 6 | Chemie (CA) |
Sequence modifications
A: -17 - 1105 (UniProt: P38570)
B: -18 - 704 (UniProt: P26010)
| PDB | External Database | Details |
|---|---|---|
| Gly 1106 | - | expression tag |
| Thr 1107 | - | expression tag |
| Gly 1108 | - | expression tag |
| Gly 1109 | - | expression tag |
| Leu 1110 | - | expression tag |
| Glu 1111 | - | expression tag |
| Val 1112 | - | expression tag |
| Leu 1113 | - | expression tag |
| Phe 1114 | - | expression tag |
| Gln 1115 | - | expression tag |
| Gly 1116 | - | expression tag |
| Pro 1117 | - | expression tag |
| Gly 1118 | - | expression tag |
| Glu 1119 | - | expression tag |
| Asn 1120 | - | expression tag |
| Ala 1121 | - | expression tag |
| Gln 1122 | - | expression tag |
| Cys 1123 | - | expression tag |
| Glu 1124 | - | expression tag |
| Lys 1125 | - | expression tag |
| Glu 1126 | - | expression tag |
| Leu 1127 | - | expression tag |
| Gln 1128 | - | expression tag |
| Ala 1129 | - | expression tag |
| Leu 1130 | - | expression tag |
| Glu 1131 | - | expression tag |
| Lys 1132 | - | expression tag |
| Glu 1133 | - | expression tag |
| Asn 1134 | - | expression tag |
| Ala 1135 | - | expression tag |
| Gln 1136 | - | expression tag |
| Leu 1137 | - | expression tag |
| Glu 1138 | - | expression tag |
| Trp 1139 | - | expression tag |
| Glu 1140 | - | expression tag |
| Leu 1141 | - | expression tag |
| Gln 1142 | - | expression tag |
| Ala 1143 | - | expression tag |
| Leu 1144 | - | expression tag |
| Glu 1145 | - | expression tag |
| Lys 1146 | - | expression tag |
| Glu 1147 | - | expression tag |
| Leu 1148 | - | expression tag |
| Ala 1149 | - | expression tag |
| Gln 1150 | - | expression tag |
| Trp 1151 | - | expression tag |
| Ser 1152 | - | expression tag |
| His 1153 | - | expression tag |
| Pro 1154 | - | expression tag |
| Gln 1155 | - | expression tag |
| Phe 1156 | - | expression tag |
| Glu 1157 | - | expression tag |
| Lys 1158 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Asp 705 | - | expression tag |
| Thr 706 | - | expression tag |
| Ser 707 | - | expression tag |
| Gly 708 | - | expression tag |
| Leu 709 | - | expression tag |
| Glu 710 | - | expression tag |
| Val 711 | - | expression tag |
| Leu 712 | - | expression tag |
| Phe 713 | - | expression tag |
| Gln 714 | - | expression tag |
| Gly 715 | - | expression tag |
| Pro 716 | - | expression tag |
| Gly 717 | - | expression tag |
| Lys 718 | - | expression tag |
| Asn 719 | - | expression tag |
| Ala 720 | - | expression tag |
| Gln 721 | - | expression tag |
| Cys 722 | - | expression tag |
| Lys 723 | - | expression tag |
| Lys 724 | - | expression tag |
| Lys 725 | - | expression tag |
| Leu 726 | - | expression tag |
| Gln 727 | - | expression tag |
| Ala 728 | - | expression tag |
| Leu 729 | - | expression tag |
| Lys 730 | - | expression tag |
| Lys 731 | - | expression tag |
| Lys 732 | - | expression tag |
| Asn 733 | - | expression tag |
| Ala 734 | - | expression tag |
| Gln 735 | - | expression tag |
| Leu 736 | - | expression tag |
| Lys 737 | - | expression tag |
| Trp 738 | - | expression tag |
| Lys 739 | - | expression tag |
| Leu 740 | - | expression tag |
| Gln 741 | - | expression tag |
| Ala 742 | - | expression tag |
| Leu 743 | - | expression tag |
| Lys 744 | - | expression tag |
| Lys 745 | - | expression tag |
| Lys 746 | - | expression tag |
| Leu 747 | - | expression tag |
| Ala 748 | - | expression tag |
| Gln 749 | - | expression tag |
| Gly 750 | - | expression tag |
| Gly 751 | - | expression tag |
| His 752 | - | expression tag |
| His 753 | - | expression tag |
| His 754 | - | expression tag |
| His 755 | - | expression tag |
| His 756 | - | expression tag |
| His 757 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 261562.9 | |
| Branched | Number of molecules | 4 |
| Total formula weight | 2346.2 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 904.1 | |
| All* | Total formula weight | 264813.2 |
