9P6E
N49P7-FR Fab in complex with BG505 MD39 SOSIP and RM20A3 Fab
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, G, M (A, C, E) | Envelope glycoprotein gp120 | polymer | 481 | 54088.3 | 3 | UniProt (Q2N0S5) | Human immunodeficiency virus 1 | BG505 MD39 SOSIP gp120 |
| 2 | B, H, N (B, D, F) | Envelope glycoprotein gp41 | polymer | 153 | 17134.3 | 3 | UniProt (Q2N0S6) | Human immunodeficiency virus 1 | BG505 MD39 SOSIP gp41 |
| 3 | C, I, O (G, J, O) | RM20A3 heavy chain | polymer | 125 | 13511.1 | 3 | Macaca mulatta | ||
| 4 | D, J, P (I, M, Q) | RM20A3 light chain | polymer | 109 | 11540.6 | 3 | Macaca mulatta | ||
| 5 | E, K, Q (H, K, P) | N49P7-FR heavy chain | polymer | 134 | 15161.0 | 3 | Homo sapiens (human) | ||
| 6 | F, L, R (L, N, R) | N49P7-FR light chain | polymer | 99 | 10476.5 | 3 | Homo sapiens (human) | ||
| 7 | AA, S, W (a, S, W) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 3 | In PDB GlyTouCan (G22768VO) | |||
| 8 | BA, CA, T, U, X... (b, c, T, U, X...) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 6 | In PDB GlyTouCan (G42666HT) | |||
| 9 | DA, V, Z (d, V, Z) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 3 | In PDB GlyTouCan (G15407YE) | |||
| 10 | AB, BB, CB, DB, EA... (E, A, F, B, C...) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 33 | Chemie (NAG) PubChem (24139) |
Sequence modifications
A, C, E: 31 - 513 (UniProt: Q2N0S5)
B, D, F: 512 - 664 (UniProt: Q2N0S6)
| PDB | External Database | Details |
|---|---|---|
| Glu 106 | Thr 105 | engineered mutation |
| Ile 271 | Met 270 | engineered mutation |
| Leu 288 | Phe 287 | engineered mutation |
| Val 304 | Arg 303 | engineered mutation |
| Tyr 319 | Ala 316 | engineered mutation |
| Asn 332 | Thr 330 | engineered mutation |
| Gln 363 | Asn 361 | engineered mutation |
| Cys 501 | Ala 498 | engineered mutation |
| Arg 509 | Glu 506 | engineered mutation |
| Arg 510 | Lys 507 | engineered mutation |
| Arg 512 | Ala 509 | engineered mutation |
| Arg 513 | Val 510 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ser 519 | Phe 516 | engineered mutation |
| Pro 559 | Ile 556 | engineered mutation |
| Pro 561 | Ala 558 | engineered mutation |
| Asp 568 | Leu 565 | engineered mutation |
| His 570 | Val 567 | engineered mutation |
| His 585 | Arg 582 | engineered mutation |
| Cys 605 | Thr 602 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 18 |
| Total formula weight | 365735.5 | |
| Branched | Number of molecules | 12 |
| Total formula weight | 7038.5 | |
| Non-Polymers* | Number of molecules | 33 |
| Total formula weight | 7299.9 | |
| All* | Total formula weight | 380073.9 |
