9P6A
The catalytic domain of MEKK2 in complex with ponatinib
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Mitogen-activated protein kinase kinase kinase 2 | polymer | 299 | 33768.8 | 2 | UniProt (Q9Y2U5) Pfam (PF00069) | Homo sapiens (human) | MAPK/ERK kinase kinase 2,MEK kinase 2,MEKK 2 |
| 2 | C, D (A, B) | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzam ide | non-polymer | 532.6 | 2 | Chemie (0LI) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 32 | Chemie (HOH) |
Sequence modifications
A, B: 325 - 619 (UniProt: Q9Y2U5)
| PDB | External Database | Details |
|---|---|---|
| Gly 321 | - | expression tag |
| Ala 322 | - | expression tag |
| Met 323 | - | expression tag |
| Gly 324 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 67537.6 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1065.1 | |
| All* | Total formula weight | 68602.7 |
