9P4Q

Cryo-EM structure of AAV.CAP-B10 complexed to AAVR-PKD2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Capsid protein VP1	polymer	743	82161.6	1	UniProt (Q6JC22)	Adeno-associated virus
2	B (R)	Dyslexia-associated protein KIAA0319-like protein	polymer	124	13587.9	1	UniProt (Q8K135)	Mus musculus (house mouse)	Adeno-associated virus receptor,AAVR

Sequence modifications

A: 1 - 743 (UniProt: Q6JC22)

PDB	External Database	Details
Asn 14	Thr 14	conflict
Glu 21	Gln 21	conflict
Ala 24	Lys 24	conflict
Ala 29	Pro 29	conflict
Gln 31	Pro 31	conflict
Ala 34	Pro 34	conflict
Asn 35	Ala 35	conflict
Gln 36	Glu 36	conflict
Gln 37	Arg 37	conflict
Gln 39	Lys 39	conflict
Asn 41	Asp 41	conflict
Ala 42	Ser 42	conflict
Ala 164	Ser 164	conflict
Arg 170	Lys 170	conflict
Asp 452	Asn 452	conflict
Ala 454	Ser 454	conflict
Ala 455	Gly 455	conflict
Thr 456	Gln 456	conflict
Lys 457	Asn 457	conflict
Asn 458	Gln 458	conflict
Asp 587	Ala 587	conflict
Gly 588	-	insertion
Thr 589	-	insertion
Leu 590	-	insertion
Ala 591	-	insertion
Val 592	-	insertion
Pro 593	-	insertion
Phe 594	-	insertion
Lys 595	Gln 588	conflict

R: 402 - 503 (UniProt: Q8K135)

PDB	External Database	Details
Gly 504	-	expression tag
Gly 505	-	expression tag
Ser 506	-	expression tag
Glu 507	-	expression tag
Gln 508	-	expression tag
Lys 509	-	expression tag
Leu 510	-	expression tag
Ile 511	-	expression tag
Ser 512	-	expression tag
Glu 513	-	expression tag
Glu 514	-	expression tag
Asp 515	-	expression tag
Leu 516	-	expression tag
Gly 517	-	expression tag
Gly 518	-	expression tag
Ser 519	-	expression tag
His 520	-	expression tag
His 521	-	expression tag
His 522	-	expression tag
His 523	-	expression tag
His 524	-	expression tag
His 525	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	95749.6
All*	Total formula weight	95749.6

*Water molecules are not included.