9P3Y

Andes virus glycoprotein tetramer in complex with ADI-65534 Fab

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C, E, G (I, K, M, O)	ADI-65534 variable heavy chain	polymer	126	14043.8	4		Homo sapiens (human)
2	B, D, F, H (J, L, N, P)	ADI-65534 variable light chain	polymer	111	12028.5	4		Homo sapiens (human)
3	I, K, M, O (A, C, E, G)	Glycoprotein N	polymer	651	72192.6	4	UniProt (Q9E006)	Orthohantavirus andesense	Glycoprotein precursor,M polyprotein
4	J, L, N, P (B, D, F, H)	Glycoprotein C	polymer	609	66793.6	4	UniProt (Q9E006)	Orthohantavirus andesense	Gc,Glycoprotein G2
5	Q, S, U, W (Q, S, U, W)	alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		910.8	4	In PDB GlyTouCan (G22768VO)
6	R, T, V, X (R, T, V, X)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	4	In PDB GlyTouCan (G42666HT)
7	AA, BA, Y, Z (E, G, A, C)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	4	Chemie (NAG)

Sequence modifications

A, C, E, G: 1 - 651 (UniProt: Q9E006)

PDB	External Database	Details
Lys 535	Val 535	engineered mutation

B, D, F, H: 652 - 1138 (UniProt: Q9E006)

PDB	External Database	Details
Leu 1096	Ser 1096	engineered mutation
Gly 1139	-	expression tag
Ser 1140	-	expression tag
Gly 1141	-	expression tag
Ser 1142	-	expression tag
Ala 1143	-	expression tag
Leu 1144	-	expression tag
Pro 1145	-	expression tag
Gly 1146	-	expression tag
Asn 1147	-	expression tag
Pro 1148	-	expression tag
Asp 1149	-	expression tag
His 1150	-	expression tag
Arg 1151	-	expression tag
Glu 1152	-	expression tag
Met 1153	-	expression tag
Gly 1154	-	expression tag
Glu 1155	-	expression tag
Thr 1156	-	expression tag
Leu 1157	-	expression tag
Pro 1158	-	expression tag
Glu 1159	-	expression tag
Glu 1160	-	expression tag
Val 1161	-	expression tag
Gly 1162	-	expression tag
Glu 1163	-	expression tag
Tyr 1164	-	expression tag
Arg 1165	-	expression tag
Gln 1166	-	expression tag
Pro 1167	-	expression tag
Ser 1168	-	expression tag
Gly 1169	-	expression tag
Gly 1170	-	expression tag
Ser 1171	-	expression tag
Val 1172	-	expression tag
Pro 1173	-	expression tag
Val 1174	-	expression tag
Ser 1175	-	expression tag
Pro 1176	-	expression tag
Gly 1177	-	expression tag
Pro 1178	-	expression tag
Pro 1179	-	expression tag
Ser 1180	-	expression tag
Gly 1181	-	expression tag
Leu 1182	-	expression tag
Glu 1183	-	expression tag
Pro 1184	-	expression tag
Thr 1185	-	expression tag
Ser 1186	-	expression tag
Ser 1187	-	expression tag
Ser 1188	-	expression tag
Pro 1189	-	expression tag
Tyr 1190	-	expression tag
Gly 1191	-	expression tag
Gly 1192	-	expression tag
Gly 1193	-	expression tag
Ser 1194	-	expression tag
Phe 1195	-	expression tag
Asn 1196	-	expression tag
Ser 1197	-	expression tag
Ser 1198	-	expression tag
Ile 1199	-	expression tag
Asn 1200	-	expression tag
Asn 1201	-	expression tag
Ile 1202	-	expression tag
His 1203	-	expression tag
Glu 1204	-	expression tag
Met 1205	-	expression tag
Glu 1206	-	expression tag
Ile 1207	-	expression tag
Gln 1208	-	expression tag
Leu 1209	-	expression tag
Lys 1210	-	expression tag
Asp 1211	-	expression tag
Ala 1212	-	expression tag
Leu 1213	-	expression tag
Glu 1214	-	expression tag
Lys 1215	-	expression tag
Asn 1216	-	expression tag
Gln 1217	-	expression tag
Gln 1218	-	expression tag
Trp 1219	-	expression tag
Leu 1220	-	expression tag
Val 1221	-	expression tag
Tyr 1222	-	expression tag
Asp 1223	-	expression tag
Gln 1224	-	expression tag
Gln 1225	-	expression tag
Arg 1226	-	expression tag
Glu 1227	-	expression tag
Val 1228	-	expression tag
Tyr 1229	-	expression tag
Val 1230	-	expression tag
Lys 1231	-	expression tag
Gly 1232	-	expression tag
Leu 1233	-	expression tag
Leu 1234	-	expression tag
Ala 1235	-	expression tag
Lys 1236	-	expression tag
Ile 1237	-	expression tag
Phe 1238	-	expression tag
Glu 1239	-	expression tag
Leu 1240	-	expression tag
Glu 1241	-	expression tag
Lys 1242	-	expression tag
Lys 1243	-	expression tag
Thr 1244	-	expression tag
Glu 1245	-	expression tag
Thr 1246	-	expression tag
Ala 1247	-	expression tag
Ala 1248	-	expression tag
Gly 1249	-	expression tag
Gly 1250	-	expression tag
Gly 1251	-	expression tag
Ser 1252	-	expression tag
His 1253	-	expression tag
His 1254	-	expression tag
His 1255	-	expression tag
His 1256	-	expression tag
His 1257	-	expression tag
His 1258	-	expression tag
His 1259	-	expression tag
His 1260	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	16
	Total formula weight	660234.0
Branched	Number of molecules	8
	Total formula weight	5340.9
Non-Polymers*	Number of molecules	4
	Total formula weight	884.8
All*	Total formula weight	666459.8

*Water molecules are not included.