9P1C

Crystal structure of human TMPRSS11A S368A interacting with its own zymogen activation motif

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Transmembrane protease serine 11A	polymer	186	21239.8	1	UniProt (Q6ZMR5)	Homo sapiens (human)	Airway trypsin-like protease 1,Epidermal type-II transmembrane serine protease,Esophageal cancer-susceptibility gene 1 protein
2	B (B)	Transmembrane protease serine 11A	polymer	232	26054.6	1	UniProt (Q6ZMR5)	Homo sapiens (human)	Airway trypsin-like protease 1,Epidermal type-II transmembrane serine protease,Esophageal cancer-susceptibility gene 1 protein
3	C, D, E, F (B)	PHOSPHATE ION	non-polymer		95.0	4	Chemie (PO4)
4	G (B)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	1	Chemie (NAG)
5	H, I (A, B)	water	water		18.0	17	Chemie (HOH)

Sequence modifications

A: 45 - 186 (UniProt: Q6ZMR5)

PDB	External Database	Details
Ala 1	-	expression tag
Ala 2	-	expression tag
Pro 3	-	expression tag
Glu 4	-	expression tag
Met 5	-	expression tag
His 6	-	expression tag
His 7	-	expression tag
His 8	-	expression tag
His 9	-	expression tag
His 10	-	expression tag
His 11	-	expression tag
Glu 12	-	expression tag
Phe 13	-	expression tag
Met 14	-	expression tag
Ser 15	-	expression tag
Gly 16	-	expression tag
Leu 17	-	expression tag
Asn 18	-	expression tag
Asp 19	-	expression tag
Ile 20	-	expression tag
Phe 21	-	expression tag
Glu 22	-	expression tag
Ala 23	-	expression tag
Gln 24	-	expression tag
Lys 25	-	expression tag
Ile 26	-	expression tag
Glu 27	-	expression tag
Trp 28	-	expression tag
His 29	-	expression tag
Glu 30	-	expression tag
Gly 31	-	expression tag
Ser 32	-	expression tag
Ala 33	-	expression tag
Gly 34	-	expression tag
Gly 35	-	expression tag
Ser 36	-	expression tag
Gly 37	-	expression tag
Glu 38	-	expression tag
Asn 39	-	expression tag
Leu 40	-	expression tag
Tyr 41	-	expression tag
Phe 42	-	expression tag
Gln 43	-	expression tag
Gly 44	-	expression tag

B: 187 - 418 (UniProt: Q6ZMR5)

PDB	External Database	Details
Ala 368	Ser 368	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	47294.4
Non-Polymers*	Number of molecules	5
	Total formula weight	601.1
All*	Total formula weight	47895.5

*Water molecules are not included.