9P0L

Composite map of CXCL10-CXCR3-Gi-scFv16

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	C-X-C chemokine receptor type 3,GFP-like fluorescent chromoprotein FP506, related	polymer	684	75792.7	1	UniProt (P49682) UniProt (U6GSR1) Pfam (PF00001) Pfam (PF01353)	Homo sapiens (human)	CXC-R3,CXCR-3,CKR-L2,G protein-coupled receptor 9,Interferon-inducible protein 10 receptor,IP-10 receptor
2	B (B)	C-X-C motif chemokine 10	polymer	77	8663.3	1	UniProt (P02778) Pfam (PF00048)	Homo sapiens (human)	10 kDa interferon gamma-induced protein,Gamma-IP10,IP-10,Small-inducible cytokine B10
3	C (C)	Guanine nucleotide-binding protein G(i) subunit alpha-1	polymer	376	43182.1	1	UniProt (P63096) Pfam (PF00503)	Homo sapiens (human)
4	D (D)	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	polymer	357	39518.1	1	UniProt (P62873) Pfam (PF25391)	Homo sapiens (human)
5	E (E)	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	polymer	71	7861.1	1	UniProt (P59768) Pfam (PF00631)	Homo sapiens (human)	G gamma-I
6	F (F)	scFv16	polymer	269	28754.9	1		Mus musculus

Sequence modifications

A: 1 - 368 (UniProt: P49682)

PDB	External Database	Details
Met -34	-	expression tag
Lys -33	-	expression tag
Thr -32	-	expression tag
Ile -31	-	expression tag
Ile -30	-	expression tag
Ala -29	-	expression tag
Leu -28	-	expression tag
Ser -27	-	expression tag
Tyr -26	-	expression tag
Ile -25	-	expression tag
Phe -24	-	expression tag
Cys -23	-	expression tag
Leu -22	-	expression tag
Val -21	-	expression tag
Phe -20	-	expression tag
Ala -19	-	expression tag
Asp -18	-	expression tag
Tyr -17	-	expression tag
Lys -16	-	expression tag
Asp -15	-	expression tag
Asp -14	-	expression tag
Asp -13	-	expression tag
Asp -12	-	expression tag
Lys -11	-	expression tag
Gly -10	-	expression tag
Ser -9	-	expression tag
Glu -8	-	expression tag
Asn -7	-	expression tag
Leu -6	-	expression tag
Tyr -5	-	expression tag
Phe -4	-	expression tag
Gln -3	-	expression tag
Ser -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag
Ala 260	Val 260	conflict
Gly 369	-	linker
Asn 370	-	linker
Ser 371	-	linker
Leu 372	-	linker
Glu 373	-	linker
Val 374	-	linker
Leu 375	-	linker
Phe 376	-	linker
Gln 377	-	linker
Gly 378	-	linker
Pro 379	-	linker

A: 380 - 618 (UniProt: U6GSR1)

PDB	External Database	Details
Leu 426	Phe 47	conflict
Leu 444	Phe 65	conflict
Gln 449	Met 70	conflict
Thr 533	Met 154	conflict
Ala 543	Val 164	conflict
Gly 555	Ser 176	conflict
Lys 586	Ala 207	conflict
Gly 619	-	expression tag
Ser 620	-	expression tag
Ala 621	-	expression tag
Trp 622	-	expression tag
Ser 623	-	expression tag
His 624	-	expression tag
Pro 625	-	expression tag
Gln 626	-	expression tag
Phe 627	-	expression tag
Glu 628	-	expression tag
Lys 629	-	expression tag
Gly 630	-	expression tag
Gly 631	-	expression tag
Gly 632	-	expression tag
Ser 633	-	expression tag
Gly 634	-	expression tag
Gly 635	-	expression tag
Gly 636	-	expression tag
Ser 637	-	expression tag
Gly 638	-	expression tag
Gly 639	-	expression tag
Ser 640	-	expression tag
Ala 641	-	expression tag
Trp 642	-	expression tag
Ser 643	-	expression tag
His 644	-	expression tag
Pro 645	-	expression tag
Gln 646	-	expression tag
Phe 647	-	expression tag
Glu 648	-	expression tag
Lys 649	-	expression tag

C: 1 - 354 (UniProt: P63096)

PDB	External Database	Details
Met -21	-	expression tag
Lys -20	-	expression tag
Lys -19	-	expression tag
His -18	-	expression tag
His -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
His -9	-	expression tag
Glu -8	-	expression tag
Asn -7	-	expression tag
Leu -6	-	expression tag
Tyr -5	-	expression tag
Phe -4	-	expression tag
Gln -3	-	expression tag
Gly -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag

D: 2 - 340 (UniProt: P62873)

PDB	External Database	Details
Met -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
His -9	-	expression tag
His -8	-	expression tag
Gly -7	-	expression tag
Glu -6	-	expression tag
Asn -5	-	expression tag
Leu -4	-	expression tag
Tyr -3	-	expression tag
Phe -2	-	expression tag
Gln -1	-	expression tag
Gly 0	-	expression tag
Ser 1	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	203772.3
All*	Total formula weight	203772.3

*Water molecules are not included.