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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9OXB

CryoEM structure of Ggust-coupled TAS2R43 with aristolochic acid I

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)		Guanine nucleotide-binding protein G(t) subunit alpha-3polymer35440339.81UniProt (A8MTJ3)
Pfam (PF00503)		Homo sapiens (human)Gustducin alpha-3 chain
2B
(B)		Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1polymer40242936.71UniProt (P62873)
Pfam (PF25391)		Homo sapiens (human)Transducin beta chain 1
3C
(C)		Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2polymer717861.11UniProt (P59768)
Pfam (PF00631)		Homo sapiens (human)G gamma-I
4D
(D)		scFv16polymer26728668.91Homo sapiens (human)
5E
(R)		Taste receptor type 2 member 43polymer64572130.31UniProt (P59537)
Pfam (PF05296)		Homo sapiens (human)T2R43,Taste receptor type 2 member 52,T2R52
6F
(R)		8-methoxy-6-nitro-naphtho[1,2-e][1,3]benzodioxole-5-carboxylic acidnon-polymer341.31Chemie (GOQ)
PubChem (2236)
7G, H
(A, R)		waterwater18.05Chemie (HOH)
Sequence modifications
A: 1 - 354 (UniProt: A8MTJ3)
PDBExternal DatabaseDetails
Thr 4Gly 4conflict
Val 5Ile 5conflict
Ala 7Ser 7conflict
Asp 9Ser 9conflict
Ala 11Glu 11conflict
Ala 12Ser 12conflict
Glu 14Lys 14conflict
Met 18Glu 18conflict
Ile 19Leu 19conflict
Asp 20Glu 20conflict
Asn 22Lys 22conflict
Arg 24Gln 24conflict
Ala 47Ser 47conflict
Gln 53Met 53conflict
Met 54Lys 54conflict
Ala 203Gly 203conflict
Ala 245Glu 245conflict
Lys 248His 248conflict
Asp 251Asn 251conflict
Asp 261Thr 261conflict
Ser 326Ala 326conflict
B: 2 - 340 (UniProt: P62873)
PDBExternal DatabaseDetails
Met -17-expression tag
His -16-expression tag
His -15-expression tag
His -14-expression tag
His -13-expression tag
His -12-expression tag
His -11-expression tag
Leu -10-expression tag
Glu -9-expression tag
Val -8-expression tag
Leu -7-expression tag
Phe -6-expression tag
Gln -5-expression tag
Gly -4-expression tag
Pro -3-expression tag
Gly -2-expression tag
Ser -1-expression tag
Ser 0-expression tag
Gly 1-expression tag
Gly 341-expression tag
Gly 342-expression tag
Ser 343-expression tag
Gly 344-expression tag
Gly 345-expression tag
Gly 346-expression tag
Gly 347-expression tag
Ser 348-expression tag
Gly 349-expression tag
Gly 350-expression tag
Ser 351-expression tag
Ser 352-expression tag
Ser 353-expression tag
Gly 354-expression tag
Gly 355-expression tag
Gly 356-expression tag
Gly 357-expression tag
Ser 358-expression tag
Gly 359-expression tag
Gly 360-expression tag
Gly 361-expression tag
Gly 362-expression tag
Ser 363-expression tag
Gly 364-expression tag
Gly 365-expression tag
Ser 366-expression tag
Ser 367-expression tag
Ser 368-expression tag
Gly 369-expression tag
Gly 370-expression tag
Val 371-expression tag
Ser 372-expression tag
Gly 373-expression tag
Trp 374-expression tag
Arg 375-expression tag
Leu 376-expression tag
Phe 377-expression tag
Lys 378-expression tag
Lys 379-expression tag
Ile 380-expression tag
Ser 381-expression tag
Gly 382-expression tag
Gly 383-expression tag
Ser 384-expression tag
R: 1 - 309 (UniProt: P59537)
PDBExternal DatabaseDetails
Asp -150-expression tag
Tyr -149-expression tag
Lys -148-expression tag
Asp -147-expression tag
Asp -146-expression tag
Asp -145-expression tag
Asp -144-expression tag
Ala -143-expression tag
Lys -142-expression tag
Leu -141-expression tag
Gln -140-expression tag
Thr -139-expression tag
Met -138-expression tag
His -137-expression tag
His -136-expression tag
His -135-expression tag
His -134-expression tag
His -133-expression tag
His -132-expression tag
His -131-expression tag
His -130-expression tag
His -129-expression tag
His -128-expression tag
Glu -127-expression tag
Asn -126-expression tag
Leu -125-expression tag
Tyr -124-expression tag
Phe -123-expression tag
Gln -122-expression tag
Gly -121-expression tag
Gly -120-expression tag
Thr -119-expression tag
Thr -118-expression tag
Met -117-expression tag
Ala -116-expression tag
Asp -115-expression tag
Leu -114-expression tag
Glu -113-expression tag
Asp -112-expression tag
Asn -111-expression tag
Trp -110-expression tag
Glu -109-expression tag
Thr -108-expression tag
Leu -107-expression tag
Asn -106-expression tag
Asp -105-expression tag
Asn -104-expression tag
Leu -103-expression tag
Lys -102-expression tag
Val -101-expression tag
Ile -100-expression tag
Glu -99-expression tag
Lys -98-expression tag
Ala -97-expression tag
Asp -96-expression tag
Asn -95-expression tag
Ala -94-expression tag
Ala -93-expression tag
Gln -92-expression tag
Val -91-expression tag
Lys -90-expression tag
Asp -89-expression tag
Ala -88-expression tag
Leu -87-expression tag
Thr -86-expression tag
Lys -85-expression tag
Met -84-expression tag
Arg -83-expression tag
Ala -82-expression tag
Ala -81-expression tag
Ala -80-expression tag
Leu -79-expression tag
Asp -78-expression tag
Ala -77-expression tag
Gln -76-expression tag
Lys -75-expression tag
Ala -74-expression tag
Thr -73-expression tag
Pro -72-expression tag
Pro -71-expression tag
Lys -70-expression tag
Leu -69-expression tag
Glu -68-expression tag
Asp -67-expression tag
Lys -66-expression tag
Ser -65-expression tag
Pro -64-expression tag
Asp -63-expression tag
Ser -62-expression tag
Pro -61-expression tag
Glu -60-expression tag
Met -59-expression tag
Lys -58-expression tag
Asp -57-expression tag
Phe -56-expression tag
Arg -55-expression tag
His -54-expression tag
Gly -53-expression tag
Phe -52-expression tag
Asp -51-expression tag
Ile -50-expression tag
Leu -49-expression tag
Val -48-expression tag
Gly -47-expression tag
Gln -46-expression tag
Ile -45-expression tag
Asp -44-expression tag
Asp -43-expression tag
Ala -42-expression tag
Leu -41-expression tag
Lys -40-expression tag
Leu -39-expression tag
Ala -38-expression tag
Asn -37-expression tag
Glu -36-expression tag
Gly -35-expression tag
Lys -34-expression tag
Val -33-expression tag
Lys -32-expression tag
Glu -31-expression tag
Ala -30-expression tag
Gln -29-expression tag
Ala -28-expression tag
Ala -27-expression tag
Ala -26-expression tag
Glu -25-expression tag
Gln -24-expression tag
Leu -23-expression tag
Lys -22-expression tag
Thr -21-expression tag
Thr -20-expression tag
Arg -19-expression tag
Asn -18-expression tag
Ala -17-expression tag
Tyr -16-expression tag
Ile -15-expression tag
Gln -14-expression tag
Lys -13-expression tag
Tyr -12-expression tag
Leu -11-expression tag
Gly -10-expression tag
Ser -9-expression tag
Thr -8-expression tag
Leu -7-expression tag
Glu -6-expression tag
Val -5-expression tag
Leu -4-expression tag
Phe -3-expression tag
Gln -2-expression tag
Gly -1-expression tag
Pro 0-expression tag
Gly 310-expression tag
Ser 311-expression tag
Ala 312-expression tag
Gly 313-expression tag
Ser 314-expression tag
Ala 315-expression tag
Gly 316-expression tag
Ser 317-expression tag
Gly 318-expression tag
Gly 319-expression tag
Ser 320-expression tag
Gly 321-expression tag
Gly 322-expression tag
Gly 323-expression tag
Ser 324-expression tag
Gly 325-expression tag
Gly 326-expression tag
Gly 327-expression tag
Gly 328-expression tag
Ser 329-expression tag
Gly 330-expression tag
Gly 331-expression tag
Ser 332-expression tag
Ser 333-expression tag
Ser 334-expression tag
Gly 335-expression tag
Gly 336-expression tag
Val 337-expression tag
Phe 338-expression tag
Thr 339-expression tag
Leu 340-expression tag
Glu 341-expression tag
Asp 342-expression tag
Phe 343-expression tag
Val 344-expression tag
Gly 345-expression tag
Asp 346-expression tag
Trp 347-expression tag
Glu 348-expression tag
Gln 349-expression tag
Thr 350-expression tag
Ala 351-expression tag
Ala 352-expression tag
Tyr 353-expression tag
Asn 354-expression tag
Leu 355-expression tag
Asp 356-expression tag
Gln 357-expression tag
Val 358-expression tag
Leu 359-expression tag
Glu 360-expression tag
Gln 361-expression tag
Gly 362-expression tag
Gly 363-expression tag
Val 364-expression tag
Ser 365-expression tag
Ser 366-expression tag
Leu 367-expression tag
Leu 368-expression tag
Gln 369-expression tag
Asn 370-expression tag
Leu 371-expression tag
Ala 372-expression tag
Val 373-expression tag
Ser 374-expression tag
Val 375-expression tag
Thr 376-expression tag
Pro 377-expression tag
Ile 378-expression tag
Gln 379-expression tag
Arg 380-expression tag
Ile 381-expression tag
Val 382-expression tag
Arg 383-expression tag
Ser 384-expression tag
Gly 385-expression tag
Glu 386-expression tag
Asn 387-expression tag
Ala 388-expression tag
Leu 389-expression tag
Lys 390-expression tag
Ile 391-expression tag
Asp 392-expression tag
Ile 393-expression tag
His 394-expression tag
Val 395-expression tag
Ile 396-expression tag
Ile 397-expression tag
Pro 398-expression tag
Tyr 399-expression tag
Glu 400-expression tag
Gly 401-expression tag
Leu 402-expression tag
Ser 403-expression tag
Ala 404-expression tag
Asp 405-expression tag
Gln 406-expression tag
Met 407-expression tag
Ala 408-expression tag
Gln 409-expression tag
Ile 410-expression tag
Glu 411-expression tag
Glu 412-expression tag
Val 413-expression tag
Phe 414-expression tag
Lys 415-expression tag
Val 416-expression tag
Val 417-expression tag
Tyr 418-expression tag
Pro 419-expression tag
Val 420-expression tag
Asp 421-expression tag
Asp 422-expression tag
His 423-expression tag
His 424-expression tag
Phe 425-expression tag
Lys 426-expression tag
Val 427-expression tag
Ile 428-expression tag
Leu 429-expression tag
Pro 430-expression tag
Tyr 431-expression tag
Gly 432-expression tag
Thr 433-expression tag
Leu 434-expression tag
Val 435-expression tag
Ile 436-expression tag
Asp 437-expression tag
Gly 438-expression tag
Val 439-expression tag
Thr 440-expression tag
Pro 441-expression tag
Asn 442-expression tag
Met 443-expression tag
Leu 444-expression tag
Asn 445-expression tag
Tyr 446-expression tag
Phe 447-expression tag
Gly 448-expression tag
Arg 449-expression tag
Pro 450-expression tag
Tyr 451-expression tag
Glu 452-expression tag
Gly 453-expression tag
Ile 454-expression tag
Ala 455-expression tag
Val 456-expression tag
Phe 457-expression tag
Asp 458-expression tag
Gly 459-expression tag
Lys 460-expression tag
Lys 461-expression tag
Ile 462-expression tag
Thr 463-expression tag
Val 464-expression tag
Thr 465-expression tag
Gly 466-expression tag
Thr 467-expression tag
Leu 468-expression tag
Trp 469-expression tag
Asn 470-expression tag
Gly 471-expression tag
Asn 472-expression tag
Lys 473-expression tag
Ile 474-expression tag
Ile 475-expression tag
Asp 476-expression tag
Glu 477-expression tag
Arg 478-expression tag
Leu 479-expression tag
Ile 480-expression tag
Thr 481-expression tag
Pro 482-expression tag
Asp 483-expression tag
Gly 484-expression tag
Ser 485-expression tag
Met 486-expression tag
Leu 487-expression tag
Phe 488-expression tag
Arg 489-expression tag
Val 490-expression tag
Thr 491-expression tag
Ile 492-expression tag
Asn 493-expression tag
Ser 494-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains5
Total formula weight191936.9
Non-Polymers*Number of molecules1
Total formula weight341.3
All*Total formula weight192278.2
*Water molecules are not included.

257179

PDB entries from 2026-07-29

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