9OVU
Composite map of GluA1/A2 in the activated state, in complex with positive allosteric modulator (R,R)-2b and agonist glutamate (ATD-LBD-TMD)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Isoform Flip of Glutamate receptor 1 | polymer | 835 | 94483.9 | 2 | UniProt (P19490) | Rattus norvegicus (Norway rat) | GluR-1,AMPA-selective glutamate receptor 1,GluR-A,GluR-K1,Glutamate receptor ionotropic,AMPA 1 |
| 2 | B, D (B, D) | Isoform Flip of Glutamate receptor 2 | polymer | 842 | 94370.0 | 2 | UniProt (P19491) | Rattus norvegicus (Norway rat) | GluR-2,AMPA-selective glutamate receptor 2,GluR-B,GluR-K2,Glutamate receptor ionotropic,AMPA 2 |
| 3 | E, G, H, I, K... (E, G, H, I, K...) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 6 | In PDB GlyTouCan (G42666HT) | |||
| 4 | F, J (F, J) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 2 | In PDB GlyTouCan (G15407YE) | |||
| 5 | M, N, P, R (A, B, C, D) | GLUTAMIC ACID | non-polymer | 147.1 | 4 | Chemie (GLU) PubChem (611) PubChem (23327) PubChem (33032) | |||
| 6 | O (B) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) PubChem (923) | |||
| 7 | Q, S (C, D) | N,N'-[biphenyl-4,4'-diyldi(2R)propane-2,1-diyl]dipropane-2-sulfonamide | non-polymer | 480.7 | 2 | Chemie (FWF) PubChem (22259901) PubChem (44468130) PubChem (44468131) | |||
| 8 | T, U, V, W (A, B, C, D) | water | water | 18.0 | 4 | Chemie (HOH) |
Sequence modifications
A, C: -11 - 823 (UniProt: P19490)
B, D: -14 - 826 (UniProt: P19491)
| PDB | External Database | Details |
|---|---|---|
| - | Ala 392 | deletion |
| - | Thr 393 | deletion |
| - | Asp 394 | deletion |
| - | Ala 395 | deletion |
| - | Gln 396 | deletion |
| - | Ala 397 | deletion |
| PDB | External Database | Details |
|---|---|---|
| Gly -13 | Gln 2 | conflict |
| Glu 241 | Asn 256 | conflict |
| Leu 382 | Val 397 | conflict |
| - | Leu 399 | deletion |
| - | Thr 400 | deletion |
| - | Glu 401 | deletion |
| - | Leu 402 | deletion |
| - | Pro 403 | deletion |
| - | Ser 404 | deletion |
| Glu 384 | Gly 405 | conflict |
| Asp 385 | Asn 406 | conflict |
| Gln 392 | Asn 413 | conflict |
| Arg 586 | Gln 607 | conflict |
| Gly 827 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 377707.8 | |
| Branched | Number of molecules | 8 |
| Total formula weight | 3719.5 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1572.9 | |
| All* | Total formula weight | 383000.1 |
